Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from <scp>HOMAGE</scp> and the <scp>UK</scp> Biobank

Rastogi, Tripti; Ho, Frederick K; Rossignol, Patrick; Merkling, Thomas; Butler, Javed; Clark, Andrew L.; Collier, Timothy J.; Delles, Christian; Jukema, Wouter; Heymans, Stéphane; Latini, Roberto; Mebazaa, Alexandre; Pellicori, Pierpaolo; Sever, Peter; Staessen, Jan A; Thijs, Lutgarde; Cleland, John G.F.; Sattar, Naveed; Zannad, Faı̈ez; Girerd, Nicolas

doi:10.1002/ejhf.2495

Cited by 9 publications

(13 citation statements)

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“…Older age, male sex and higher heart rate were associated with an increased risk of HF in all subjects, whereas lower renal function had a stronger association with HF in patients with a history of MI, and higher body mass index, hypertension and blood glucose were significant only in patients without a history of MI. These data were confirmed in the UK Biobank (validation cohort) 4 …”

Section: Preventionmentioning

confidence: 99%

“…Myocardial infarction (MI) is a major cause of heart failure (HF) 1–3 . Rastogi et al 4 . showed different characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE (Heart ‘OMics’ in AGEing) cohort.…”

Section: Preventionmentioning

confidence: 99%

“…These data were confirmed in the UK Biobank (validation cohort). 4 Chronic kidney disease (CKD) is a major risk factor for HF. 2,5 Janus et al 6 investigated the usefulness of biomarkers to predict the risk of HF in 3182 patients with CKD in the Chronic Renal Insufficiency Cohort (CRIC).…”

mentioning

confidence: 99%

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Myocardial infarction (MI) is a major cause of heart failure (HF). [1][2][3] Rastogi et al 4 showed different characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE (Heart 'OMics' in AGEing) cohort. Older age, male sex and higher heart rate were associated with an increased risk of HF in all subjects, whereas lower renal function had a stronger association with HF in patients with a history of MI, and higher body mass index, hypertension and blood glucose were significant only in patients without a history of MI.

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mentioning

confidence: 99%

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June 2022 at a glance: prevention, outcomes and treatment

Tomasoni

Adamo

Metra

2022

European J of Heart Fail

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Myocardial infarction (MI) is a major cause of heart failure (HF). [1][2][3] Rastogi et al. 4 showed different characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE (Heart 'OMics' in AGEing) cohort. Older age, male sex and higher heart rate were associated with an increased risk of HF in all subjects, whereas lower renal function had a stronger association with HF in patients with a history of MI, and higher body mass index, hypertension and blood glucose were significant only in patients without a history of MI. These data were confirmed in the UK Biobank (validation cohort). 4 Chronic kidney disease (CKD) is a major risk factor for HF. 2,5 Janus et al. 6 investigated the usefulness of biomarkers to predict the risk of HF in 3182 patients with CKD in the Chronic Renal Insufficiency Cohort (CRIC). Four biomarkers -B-type natriuretic peptide, fibroblast growth factor-23, fibrinogen and high-sensitivity troponin T -were associated with incident HF after adjustment for other risk factors and their inclusion allowed a better risk stratification for incident HF. Acute myocarditisOutcomes of acute myocarditis are not clearly defined. 3,22,23 A total of 466 consecutive patients, with clinically suspected or biopsy-proven myocarditis, were enrolled in a single centre prospective study from 1992 to 2012. Survival free from death or heart transplantation at 10 years was 83% and was lower in biopsy-proven versus clinically suspected myocarditis (76% vs. 94%, p < 0.001). Female gender, fulminant presentation, anti-nuclear antibodies and lower LVEF were predictors of death or heart transplantation. 24

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Section: Preventionmentioning

confidence: 99%

Section: Preventionmentioning

confidence: 99%

mentioning

confidence: 99%

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mentioning

confidence: 99%

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June 2022 at a glance: prevention, outcomes and treatment

Tomasoni

Adamo

Metra

2022

European J of Heart Fail

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“…Against this background, in this issue of the Journal, the study by Rastogi et al 9 provides new insights into the modifying effects of MI on risk factors for HF. The authors used data from 26 478 participants of the Heart 'OMics' in AGEing (HOMAGE) database to investigate whether a previous history of MI modified the association between risk factors and incident HF hospitalization.…”

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confidence: 99%

Risk factors for the development of heart failure in patients with or without prior myocardial infarction

Essen

Voors

Tromp

2022

European J of Heart Fail

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This article refers to 'Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank' by T. Rastogi et al., published in this issue on pages 976-984.One in five men and women will develop heart failure (HF) during their lifetime. 1 Once patients have developed HF, their mortality and morbidity are high. 2 Identifying those patients at risk for the development of HF is therefore important. In particular, modifiable risk factors -like hypertension, hypercholesterolaemia, obesity, smoking and diabetes mellitus -have the potential to prevent HF and are cost-effective public health interventions. 3,4 Cardiac ischaemia, through either a previous myocardial infarction (MI) or coronary artery disease (CAD), is among the chief risk factors for developing HF. 5,6 From studies in patients with prevalent HF we learned that patients with ischaemia and HF have unique characteristics: they are more often men, rather have HF with reduced ejection fraction (HFrEF) than HF with preserved ejection fraction (HFpEF), and have more comorbidities. 7 Importantly, network analysis of proteins highlighted activation of unique pathophysiological pathways in patients with ischaemia, relating to inflammation, endothelial dysfunction, coagulation and atherosclerosis. 8 Whether cardiac ischaemia influences the association of risk factors for incident HF is important to design effective prevention strategies.Against this background, in this issue of the Journal, the study by Rastogi et al. 9 provides new insights into the modifying effects of MI on risk factors for HF. The authors used data from 26 478 participants of the Heart 'OMics' in AGEing (HOMAGE) database to investigate whether a previous history of MI modified the association between risk factors and incident HF hospitalization. Their results were validated in 500 001 participants from the UK The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology.

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Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status

Dawson,

Carrington,

Haregu

et al. 2023

ESC Heart Failure

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AimsHeart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the association between incident HF with baseline status across these domains, overall and separated according to ASCVD status.Methods and resultsWe included 5758 participants from the Baker Biobank cohort without HF at baseline enrolled between January 2000 and December 2011. The primary endpoint was incident HF, defined as hospital admission or HF‐related death, determined through linkage with state‐wide administrative databases (median follow‐up 12.2 years). Regression models were fitted adjusted for sociodemographic variables, alcohol intake, smoking status, measures of adiposity, cardiometabolic profile measures, and individual comorbidities. During 65 987 person‐years (median age 59 years, 38% women), incident HF occurred among 784 participants (13.6%) overall. Rates of incident HF were higher among patients with ASCVD (624/1929, 32.4%) compared with those without ASCVD (160/3829, 4.2%). Incident HF was associated with age, socio‐economic status, alcohol intake, smoking status, body mass index (BMI), waist circumference, waist–hip ratio, systolic blood pressure (SBP), and low‐ and high‐density lipoprotein cholesterol (LDL‐C and HDL‐C), with non‐linear relationships observed for age, alcohol intake, BMI, waist circumference, waist–hip ratio, SBP, LDL‐C, and HDL‐C. Risk factors for incident HF were largely consistent regardless of ASCVD status, although diabetes status had a greater association with incident HF among patients without ASCVD.ConclusionsIncident HF is associated with a broad range of baseline sociodemographic, lifestyle, cardiometabolic, and comorbidity factors, which are mostly consistent regardless of ASCVD status. These data could be useful in efforts towards developing risk prediction models that can be used in patients with ASCVD.

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Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank

Abstract: Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE cohort and validated our results in UK Biobank.

Cited by 9 publications

References 42 publications

June 2022 at a glance: prevention, outcomes and treatment

June 2022 at a glance: prevention, outcomes and treatment

Risk factors for the development of heart failure in patients with or without prior myocardial infarction

Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status

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