Comparing baseline and reaction samples of perioperative anaphylaxis patients reveals IL‐6 and CCL2 as potential biomarkers

Callesen, Katrine T; Poulsen, Lars K.; Garvey, Lene Heise; Jensen, Bettina M.

doi:10.1111/cea.13969

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Chemokines play a role in attracting and guiding different families of leukocytes [103]. Among these, CCL-2, also known as monocyte chemoattractant protein (MCP-1), has been found increased in mice models and human anaphylactic samples [104][105][106]. In addition, a study conducted in serum from pediatric patients with anaphylaxis also demonstrated the increase of this chemokine, as well as CCL-11 [107].…”

Section: Cytokines and Chemokinesmentioning

confidence: 99%

“…Serum levels of IL-2, IL-4, IL-5, IL-6, IL-10 and IL-13 have been detected increased in patients with severe anaphylaxis [54]. Among these, IL-2, IL-6 and IL-10 correlates with severity of the episodes, histamine concentration and the occurrence of hypotension [54,106,111]. Specifically, mouse anaphylactic models show that IL-6 is released within the first few hours after allergen exposure [112].…”

Section: Interleukinsmentioning

confidence: 99%

“…Specifically, mouse anaphylactic models show that IL-6 is released within the first few hours after allergen exposure [112]. In humans, high levels of IL6 have been observed in hypersensitibiy reactions and anaphylaxis induced by monoclonal antibodies as well as in perioperative patients [106,113]. On the other hand, IL-33 has been seen to promotes oral anaphylaxis after epicutaneous sensitization in experimental murine models [114].…”

Section: Interleukinsmentioning

confidence: 99%

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Anaphylaxis: Mediators, Biomarkers, and Microenvironments

Fernández-Bravo¹,

Palacio-Garcia²,

Requena-Robledo³

et al. 2022

J Investig Allergol Clin Immunol

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The life-threating nature of the anaphylactic reactions promotes a growing interest to discover new biomarkers that could support their better diagnosis and prevention. However, both the clinical features and the etiopathology of anaphylaxis are very diverse, hindering the elucidation of valuable molecular indicators of disease. Most studies of anaphylaxis have focused on the immune system. Precisely, anaphylactic reactions are characterized primarily by IgE-mediated activation of mast cells and basophils and the release of several mediators. Among them, determinations of the serum tryptase levels is the main in vitro test used to confirm the reaction and there are no available biomarkers with predictive capacity for this pathological event. However, recent research has postulated that alternative pathways, cell types and systems are involved. Consequently, different molecular products have been explored and indicated as potential biomarkers, but none of them have been translated into the clinical practice yet. Precisely, vasoactive agents, proteases, proteoglycans, lipids, interleukins, cytokines, products of the complement-contact and coagulation systems, circulating proteins, extracellular vesicles, microRNAs and metabolites have been found to be altered in patients with anaphylaxis. The recognition of biological processes and molecular pathways interacting in the magnitude of the microenvironments switched on in anaphylaxis will notably nourish the clinical practice and the recognition of better molecular markers. Therefore, this article covers a broad review of the different mediators described in anaphylaxis and their proposal as biomarkers of this pathological event, as well as their role in the molecular basis of the reaction.

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Section: Cytokines and Chemokinesmentioning

confidence: 99%

Section: Interleukinsmentioning

confidence: 99%

Section: Interleukinsmentioning

confidence: 99%

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Anaphylaxis: Mediators, Biomarkers, and Microenvironments

Fernández-Bravo¹,

Palacio-Garcia²,

Requena-Robledo³

et al. 2022

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Inflammatory cytokine biomarkers, such as TNF-α, IL-6, and IL-1β, can be increased in serum of patients with anaphylaxis and cytokine storm-like reactions, but their sensitivity or specificity is still not demonstrated [2]. A recent study comparing baseline and reaction samples in perioperative anaphylaxis revealed IL-6 and CCL2 as potential biomarkers [96].…”

Section: Other Potential Biomarkers For Diagnosis Of Anaphylaxis In the Acute Care Settingmentioning

confidence: 99%

State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics

Simionescu

Stănescu

Popescu

2021

Life

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Anaphylaxis is an unpredictable systemic hypersensitivity reaction and constitutes a high risk of maternal and fetal morbidity and mortality when occurring during pregnancy. Currently, the acute management of anaphylaxis is based on clinical parameters. A total serum tryptase is only used to support an accurate diagnosis. There is a need to detect other biomarkers to further assess high-risk patients in obstetrics. Our objective is to present biomarkers in this complex interdisciplinary approach beyond obstetrician and anaesthetic management. Candidate biomarkers derive either from mediators involved in immunopathogenesis or upcoming molecules from systems biology and proteomics. Serum tryptase is determined by singleplex immunoassay method and is important in the evaluation of anaphylactic mast cell degranulation but also in the assessment of other risk factors for anaphylaxis such as systemic mastocytosis. Another category of biomarkers investigates the IgE-mediated sensitization to triggers potentially involved in the etiology of anaphylaxis in pregnant women, using singleplex or multiplex immunoassays. These in vitro tests with natural extracts from foods, venoms, latex or drugs, as well as with molecular allergen components, are useful because in vivo allergy tests cannot be performed on pregnant women in such a major medical emergency due to their additional potential risk of anaphylaxis.

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“…A prospective study by Perales-Chorda et al 4 addresses an unmet need to improve the diagnosis of anaphylaxis and investigates biomarkers 5 that predict the severity and outcome of this condition.…”

Section: Unmet Needs In Food Allergymentioning

confidence: 99%