Comparing Early Postoperative Period Analgesic Effect of Dexketoprofene Trometamol and Lornoxicam in Mediastinoscopy Cases

Abstract

Objective: In this study, we aimed comparing early postoperative period analgesic effectiveness and the effects on opioid consumption of intravenous dexketoprofen and lornoxicam that are given preemptively. Materials and Methods:Forty patients, planned elective mediastinoscopy, were included in this prospective randomized study. These patients were classified in two groups, group D for dexketoprofene trometamol and group L for lornoxicam, randomly. 20 minutes before the operation 50 mg dexketoprofene trometamol and 8 mg lornoxicam were injected intravenously for group D and group L respectively. In postoperative intensive care unit, pain scores, mean arterial pressures, heart rates and peripheric O2 saturations of patients were recorded at 0, 10, 20, 60, 90 and 120 th minutes.Results: When we evaluate the VAS score of the groups, there was a significant decrease in group D in all measured timesstatistically compairing to group L (p<0.001). When both group were evaluated in itself according to 0 minute time, in group L there was a significant decrease at 10 minutes time (p<0.0001) but in group D there was not a significant decrease (p>0.05). Conclusion:Since intravenous dexketoprofen, applied preemptively, has more potent analgesic effect and causing less opioid consumption in early postoperative period, is better than intravenous lornoxicam. Sonuç: Preemptif uygulanan intravenöz deksketoprofen, erken postoperatif dönemdeki analjezik etkinliği ve daha az opioid tüketimi ile IV lornoksikam'dan üstündür.

Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

“…of DEX (Eroglu, Durmus, & Kiresi, ; Esparza‐Villalpando et al, ; Iohom, Walsh, Higgins, & Shorten, ; Kara, Tuncer, Erol, & Reisli, ; Kesimci, Gümüs, & Kanbak, ), while the other studies employed intravenous (i.v.) administration (Atalay, Dogan, & Kizilkaya, ; Bolat, Erhan, & Deniz, ; Çağiran, Eyigör, & Sezer, ; Gelir, ; Gülhaş et al, ; Kadıoğlu, Tüker, Gurbet, Demirci, & Hülagü, ; Kelsaka, Guldogus, & Cetinoglu, ; Sagiroglu, ; Ozer et al, ). Eight studies utilized DEX 50 mg (Atalay et al, ; Bolat et al, ; Çağiran et al, ; Gelir, ; Gülhaş et al, ; Kadıoğlu et al, ; Kelsaka et al, ; Ozer et al, ), while the remaining studies evaluated DEX 25 mg (Esparza‐Villalpando et al, ; Iohom et al, ; Kara et al, ; Kesimci et al, ; Ozer et al, ; Sagiroglu, ).…”

“…G€ ulhaş et al (2011) reported lower opioid consumption and postoperative pain, favoring preoperative Lornoxicam. On the other hand, Sagiroglu (2011) reported lower postoperative pain favoring preoperative administration of DEX.…”

“…Two studies reported this comparison (Gülhaş et al, ; Sagiroglu, ). These articles reported opposite results.…”