Comparing Fundus Fluorescein Angiography and Swept-Source Optical Coherence Tomography Angiography in the Evaluation of Diabetic Macular Perfusion

Mantia, Alberto La; Kurt, Rengin Aslıhan; Mejor, Samantha; Egan, Catherine; Tufail, Adnan; Keane, Pearse A.; Sim, Dawn A

doi:10.1097/iae.0000000000002045

Cited by 59 publications

(36 citation statements)

References 31 publications

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“…OCTA is capable of producing highly reproducible FAZ images. [ 8 , 28 , 29 ] and has been shown to reliably identify the changes of the perifoveal capillary circulation. [ 30 ] Since the perifoveal capillary circulation seems only differed in terms of oxygen saturation and blood flow velocity,[ 25 , 26 ] the solid results of the FAZ measurements are believed to be reliable and robust.…”

Section: Discussionmentioning

confidence: 99%

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Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

Frueh

Steinmair

et al. 2018

PLoS ONE

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PurposeTo analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA).MethodsProspective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol.ResultsThirteen eyes of 12 patients met the inclusion criteria. There was a significant increase of perfusion and vessel densities in both the SCP and the DCP after cataract surgery within the 3 × 3 mm images. Significantly better distinguishability of FAZ border was observed postoperatively in both SCP and DCP, however, FAZ area and perimeter measurements did not significantly change after cataract surgery. Mean number of motion artifacts in SCP and DCP numerically decreased by 37% (P = .089) and 42% (P = .080).ConclusionsLens opacities have a significant influence on retinal blood flow measurements in SS-OCTA and should be considered in quantitative vessel analysis. Inflammation may also impact the assessment of density parameters. FAZ measurements seems to be the most robust parameters in terms of media opacity.

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Section: Discussionmentioning

confidence: 99%

“…[ 6 , 7 ] Nevertheless, respective artefacts were believed not to interfere with qualitative image interpretation. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

Frueh

Steinmair

et al. 2018

PLoS ONE

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“…9 Optical coherence tomography angiography (OCTA) is an advanced retinal imaging modality that does not require pupillary dilation or intravenous dye injection and is, therefore, an ideal tool to study vascular eye findings in pregnancy. [10][11][12] In addition, OCTA provides high-contrast depth-resolved visualization of the retinal microvasculature and automated or semiautomated quantitative analysis. OCTA uses decorrelation signals that arise Copyright 2019 The Authors iovs.arvojournals.org j ISSN: 1552-5783 from the movement of erythrocytes within blood vessels taken from sequential B-scans at the same location and can produce en face images of the retinal microcirculation.…”

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confidence: 99%

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Chanwimol

Balasubramanian

Nassisi

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate retinal vascular status during pregnancy by using optical coherence tomography angiography (OCTA). METHODS. Women in their third trimester of pregnancy and nonpregnant age-matched women were recruited for this prospective, case-control study. Subjects were imaged with OCTA. Main outcome measures were foveal avascular zone parameters, perfusion density (PD) percentage in the superficial retinal capillary plexus (SCP), PD percentage in the deep retinal capillary plexus (DCP), SCP vessel length density (VLD), DCP-VLD, and choriocapillaris (CC) flow voids (i.e., flow deficits in the CC). RESULTS. Nineteen eyes of 10 pregnant subjects and 44 eyes of 27 nonpregnant control women were included. Mean ages were 36 6 7 and 35 6 8 years (SD), respectively (P value ¼ 0.78). Mean gestational age of pregnant women was 33 weeks (range ¼ 29-39, SD ¼ 3). There was a significant reduction in the SCP-PD in the entire scan and in the nasal Early Treatment Diabetic Retinopathy Study subfield (47.9 vs. 49.7, P ¼ 0.04 and 49.3 vs. 51.6, P ¼ 0.03, respectively) in the pregnant cohort versus controls. There was a significant increase in the DCP-PD in the parafoveal region and in the temporal and inferior Early Treatment Diabetic Retinopathy Study subfields (58.0 vs. 55.9, P ¼ 0.03; 57.9 vs. 55.5, P ¼ 0.02; 58.0 vs. 55.9, P ¼ 0.05, respectively) in the pregnant cohort. There was no significant difference in foveal avascular zone parameters, SCP-VLD, DCP-VLD, or CC flow voids between the two populations. CONCLUSIONS. This study detected retinal vasculature changes in the third trimester of pregnancy. Mean SCP-PD was significantly decreased and mean DCP-PD was significantly increased without a difference in VLD.

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“…However, this absence of the "leakage blur" allows OCTA to generate considerably higher quality images of microvascular structures, even when the vessel wall is leaky [74]. Lesions that have slow flow would not be detected by OCTA such as in subtypes of microaneurysms [74][75][76] and fibrotic neovascularization [77]. Since OCTA relies on contrast between consecutive B-scans, it will detect flow only above a minimum threshold, which is affected by the time between the two sequential OCT B-scans.…”

Section: Comparison Of Optical Coherence Tomography Angiography and Fmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

Chua

Sim

Tan

et al. 2020

JCM

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Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features associated with DR, including microaneurysms and neovascularization and the quantification of alterations in retinal capillary and choriocapillaris, thereby suggesting a promising role for OCTA as an objective technology for accurate DR classification. Of interest is the potential of OCTA to examine the effect of DR on individual retinal layers, and to detect DR even before it is clinically detectable on fundus examination. We will focus the review on the clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR. Future studies with longitudinal design of multiethnic multicenter populations, as well as the inclusion of pertinent systemic information that may affect vascular changes, will improve our understanding on the benefit of OCTA biomarkers in the detection and progression of DR.

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Comparing Fundus Fluorescein Angiography and Swept-Source Optical Coherence Tomography Angiography in the Evaluation of Diabetic Macular Perfusion

Cited by 59 publications

References 31 publications

Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

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