Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties

Ross, Aisling M.; Kennedy, Tadhg; McNulty, David; Leahy, Ciara I.; Walsh, Darragh R.; Murray, P. T.; Grabrucker, Andreas M.; Mulvihill, John J.

doi:10.1016/j.msec.2020.110985

Cited by 11 publications

(15 citation statements)

References 54 publications

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“…Currently, the translation of nanoparticles from bench to bedside is hampered by the controversial results obtained between their in vitro and in vivo features. In particular, it would be useful to investigate their behavior not only in their "original media" (i.e., in the solvent used during the preparation procedure) but also in physiological media to evaluate their performance once administered in the body [9].…”

Section: Physico-chemical Characterization Of Protein-based Nanoparticlesmentioning

confidence: 99%

“…Recently, Ross et al investigated the variations of the physico-chemical features of gold, titanium, silver, and iron oxide nanostructures, using Dulbecco's modified eagle medium as dispersant [9]. This was done to simulate the injection of the nanoparticles following intravenous administration for drug delivery [9]. Among these, the silver-and gold-based nanocarriers were the most stable as they showed no consistent variations in their diameter after 24 h incubation.…”

Section: Introductionmentioning

confidence: 99%

“…It was discovered that these investigations should be performed before the in vivo experiments to avoid potentially detrimental parameters during the administration of the systems [26]. A similar approach was used for alginate-based, solid, lipid microparticles proposed for the lung delivery of fluticasone propionate [27] and recently, for metallic-and silica-based nanosystems [9,28]. The SMLS technique is used to obtain qualitative information concerning the stability kinetic of formulations used for biomedical, pharmaceutical, and industrial applications [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Influence of the Dispersion Medium and Cryoprotectants on the Physico-Chemical Features of Gliadin- and Zein-Based Nanoparticles

et al. 2022

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The evaluation of the physico-chemical features of nanocarriers is fundamental because the modulation of these parameters can influence their biological and in vivo fate. This work investigated the feasibility of saline, 5% w/v glucose and phosphate-buffered saline solution, as polar media for the development of nanoparticles made up of two vegetal proteins, zein from corn and gliadin from wheat, respectively. The physico-chemical features of the various systems were evaluated using dynamic and multiple light scattering techniques, and the results demonstrate that the 5% w/v glucose solution is a feasible medium to be used for their development. Moreover, the best formulations were characterized by the aforementioned techniques following the freeze-drying procedure. The aggregation of the zein nanoparticles prepared in water or glucose solution was prevented by using various cryoprotectants. Mannose confirmed its crucial role in the cryopreservation of the gliadin nanosystems prepared in both water and glucose solution. Sucrose and glucose emerged as additional useful excipients when they were added to gliadin nanoparticles prepared in a 5% glucose solution. Specifically, their protective effect was in the following order: mannose > sucrose > glucose. The results obtained when using specific aqueous media and cryoprotectants permitted us to develop stable zein or gliadin nanoparticles as suspension or freeze-dried formulations.

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Section: Physico-chemical Characterization Of Protein-based Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of the Dispersion Medium and Cryoprotectants on the Physico-Chemical Features of Gliadin- and Zein-Based Nanoparticles

et al. 2022

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“…Ross et al characterized different MNPs (Au, Ag, Fe2O3, TiO2, and ZnO) under the conditions of physiological fluids and water. The properties differed with the type of MNP, size, and concentration; Au and Ag NPs are found to be more stable than others [28].…”

Section: Properties Of Mnpsmentioning

confidence: 94%

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair¹,

Morsy²,

Shinu³

et al. 2021

J Pharm Pharm Sci

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Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many reviews on iron MNPs for biomedical application. Hence, in this review, we focus on non-iron MNPs and their vivid biomedical applications. Here, we review the applications of non-iron MNPs in biomedicine such as drug delivery, gene delivery, anticancer activity, antimicrobial activity, tissue engineering, bioimaging, and photodynamic, and photothermal therapies.

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“…[7,16,26] In addition, metal/metal oxide NPs have been widely used as functional materials for imaging, [27] sensing, [28] catalysis, [29] antimicrobial, [30] virus detection, [31] and medicine. [32] Notably, the excellent properties of these NPs are significantly originated from their optical property, magnetism, small size, surface plasmons, and low toxicity. [33] Recently, metal/metal oxide NPs, as one of the most prevailing materials, have attracted much attention in modern agricultural field, due to their remarkable antimicrobial activity, even at extremely low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Eco‐Friendly Nanoplatforms for Crop Quality Control, Protection, and Nutrition

et al. 2021

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Agricultural chemicals have been widely utilized to manage pests, weeds, and plant pathogens for maximizing crop yields. However, the excessive use of these organic substances to compensate their instability in the environment has caused severe environmental consequences, threatened human health, and consumed enormous economic costs. In order to improve the utilization efficiency of these agricultural chemicals, one strategy that attracted researchers is to design novel eco‐friendly nanoplatforms. To date, numerous advanced nanoplatforms with functional components have been applied in the agricultural field, such as silica‐based materials for pesticides delivery, metal/metal oxide nanoparticles for pesticides/mycotoxins detection, and carbon nanoparticles for fertilizers delivery. In this review, the synthesis, applications, and mechanisms of recent eco‐friendly nanoplatforms in the agricultural field, including pesticides and mycotoxins on‐site detection, phytopathogen inactivation, pest control, and crops growth regulation for guaranteeing food security, enhancing the utilization efficiency of agricultural chemicals and increasing crop yields are highlighted. The review also stimulates new thinking for improving the existing agricultural technologies, protecting crops from biotic and abiotic stress, alleviating the global food crisis, and ensuring food security. In addition, the challenges to overcome the constrained applications of functional nanoplatforms in the agricultural field are also discussed.

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Comparing nanoparticles for drug delivery: The effect of physiological dispersion media on nanoparticle properties

Cited by 11 publications

References 54 publications

Influence of the Dispersion Medium and Cryoprotectants on the Physico-Chemical Features of Gliadin- and Zein-Based Nanoparticles

Influence of the Dispersion Medium and Cryoprotectants on the Physico-Chemical Features of Gliadin- and Zein-Based Nanoparticles

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Eco‐Friendly Nanoplatforms for Crop Quality Control, Protection, and Nutrition

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