Comparing Percutaneous Vertebroplasty and Conservative Therapy for Treating Osteoporotic Compression Fractures in the Thoracic and Lumbar Spine

Abstract

Up to 1 year postoperatively, the effect of PVP exceeded the effect of conservative therapy with respect to pain relief in patients with osteoporotic compression fractures. The effect size was significant and close to the minimal clinically important difference.

Review of Vertebral Augmentation: An Updated Meta-analysis of the Effectiveness

“…There were also insufficient data to determine differences in extravasation rates or serious adverse events. We demonstrated comparable findings to those of a recent meta-analysis comparing NSM with VP by Mattie et al 60 When evaluating 11 studies containing 1048 participants, Mattie et al 60 reported VP was better than NSM with respect to pain relief up to 1 year after VP. This provides additional information supportive of the efficacy of VP, similar to previous meta-analyses by Anderson et al 53 and Papanastassiou et al 52 and trends shown in several of the 25 articles included in this meta-analysis.…”

“…This provides additional information supportive of the efficacy of VP, similar to previous meta-analyses by Anderson et al 53 and Papanastassiou et al 52 and trends shown in several of the 25 articles included in this meta-analysis. The level of evidence of the meta-analysis of Mattie et al 60 was designated as Oxford Level I, which should be taken into account by not only treatment guidelines but also policy recommendations and HTAs. The meta-analysis also focused specifically on percutaneous vertebroplasty as compared with conservative therapy, while only evaluating studies in which the primary outcome was pain relief.…”

HER2-Positive Breast Cancer: Tumor-to-Liver SUV Ratio is the Best Parameter for Detection in F-18 FDG-PET/CT

“…Percutaneous vertebroplasty (PV) is a well-established treatment for stabilization of vertebral bodies in both vertebral fractures and vertebral metastasis (1). Osteoporosis is the most common cause of fractures occurring at different anatomical sites, and one of the most common is fracture of vertebral bodies (2,3).…”

Efficacy of Vertebral Augmentation for Vertebral Compression Fractures: A Review of Meta-Analyses

“…Of the 10 meta-analyses, three compared both VP and KP against control cohort [8][9][10] and seven compared VP to control cohorts. [11][12][13][14][15][16][17] Characteristics and findings of the 10 studies are summarized in Table 1. When combined, the 10 meta-analyses examined a total of 22 trials.…”