Comparing Short-Duration Electro-Oculograms with and without Mydriasis in Healthy Subjects

Türksever, Cengiz; Orgül, Selim; Todorova, Margarita G.

doi:10.1055/s-0034-1396330

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…A-and b-wave amplitudes of the dark-adapted 3.0 ERG (maximal or standard combined 3.0 cd.s/m 2 rod-cone response) and of the light-adapted 3.0 ERG (single-flash 3.0 cd.s/m 2 cone response) were analysed. EOG recordings were performed on Retiscan equipment (Roland Consult System, GmbH, Brandenburg) [31].…”

Section: Electrophysiologymentioning

confidence: 99%

Linking the Presence of Macular Oedema to Structural and Functional Alterations in Retinitis Pigmentosa

Friesacher

Torres

Valmaggia

et al. 2021

Klin Monbl Augenheilkd

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Objective To investigate the association between the central retinal thickness (CRT), the retinal nerve fibre layer thickness (RNFL), and the functional alterations in retinitis pigmentosa (RP) patients. Methods Forty-three patients with typical RP and nineteen age-matched controls, who underwent SD-OCT (macular and optic disc OCT protocols) and electrophysiology, were included. The RP group was divided into two subgroups: with clinical appearance of macular oedema (ME-RP; 30 eyes) and without macular oedema (no-ME; 44 eyes). Central retinal thickness OCT data were averaged in three zones (zone 1 [0°–3°], zone 2 [3°–8°], and zone 3 [8°–15°]) and were evaluated in relation to the RNFL thickness and electrophysiological data. Results The ME-RP group showed increased CRT (zone 1) and RNFL thickness compared to the controls and no-ME-RP (p ≤ 0.002). The no-ME-RP group had reduced CRT thickness (all zones; p ≤ 0.018) compared to the controls and ME-RP, whereas the RNFL thickness in the no-ME-RP group was reduced only compared to the ME-RP group (p < 0.001). The ME-RP group showed significantly more attenuated functional responses than the no-ME-RP patients. A significant positive interaction was found between the CRT (zones 1 and 2) and the RNFL thickness within ME-RP (p ≤ 0.010). Significant negative interactions were found between CRT, RNFL thickness, and functional findings within ME-RP (p ≤ 0.049). Conclusion The presence of macular oedema correlated well with increased RNFL thickness and residual function in RP patients. Such association provides evidence of an underlying transneuronal mechanism of retinal degeneration. Simultaneous monitoring of CRT and RNFL thickness may help in the future to evaluate the progression of the disease and the efficacy of treatments in RP patients.

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Section: Electrophysiologymentioning

confidence: 99%

Linking the Presence of Macular Oedema to Structural and Functional Alterations in Retinitis Pigmentosa

Friesacher

Torres

Valmaggia

et al. 2021

Klin Monbl Augenheilkd

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“…Fast oscillations were set at 1.5 s, six cycles with a total cycle duration of 75 s. The dark phase of the recording included a pre-adaptation of 6 min followed by alternate fixation with 4-min duration and 20-s pause. The light phase (total duration: 14 min) included 4-min adaptation to light, followed by alternate fixation with 10-min duration and fixation-rest of 20 s. 32 Amplifier was bandpass filtered between 0.1 and 50 Hz. We analyzed the dark-trough amplitude, following the offset of retinal illumination, and the light-peak amplitude, following the re-illumination.…”

Section: Electrooculogrammentioning

confidence: 99%

Preserved functional and structural integrity of the papillomacular area correlates with better visual acuity in retinitis pigmentosa

Konieczka

Bojinova

Valmaggia

et al. 2016

Eye

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PurposeLinking multifocal electroretinography (mfERG) and optical coherence tomography (OCT) findings with visual acuity in retinitis pigmentosa (RP) patients.DesignProspective, cross-sectional, nonintervention study.SubjectsPatients with typical RP and age-matched controls, who underwent SD-OCT (spectral domain OCT) and mfERG, were included.MethodsMfERG responses were averaged in three zones (zone 1 (0°-3°), zone 2 (3°-8°), and zone 3 (8°-15°)). Baseline-to-trough- (N1) and trough-to-peak amplitudes (N1P1) of the mfERG were compared with corresponding areas of the OCT. The papillomacular area (PMA) was analyzed separately. Correlations between best-corrected visual acuity (BCVA, logMAR) and each parameter were determined.Main outcome measuresComparing structural (OCT) and functional (mfERG) measures with the BCVA.ResultsIn RP patients, the N1 and N1P1 responses showed positive association with the central retinal thickness outside zone 1 (P≤0.002), while the central N1 and the N1P1 responses in zones 1, 2, and 3-with the BCVA (P≤0.007). The integrity of the IS/OS line on OCT showed also a positive association with the BCVA (P<0.001). Isolated analysis of the PMA strengthened further the structure-function association with the BCVA (P≤0.037). Interactions between the BCVA and the OCT, respectively, the mfERG parameters were more pronounced in the RP subgroup without macular edema (P≤0.020).ConclusionIn RP patients, preserved structure-function of PMA, measured by mfERG amplitude and OCT retinal thickness, correlated well with the remaining BCVA. The subgroup analyses revealed stronger links between the examined parameters, in the RP subgroup without appearance of macular edema.

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“…The EOG waveforms were recorded using the Natus EMG/NCV/EP machine (USA). Pupils were not dilated as it was shown that application of pupillary dilatation does not influence the quality or the results of electrooculograms [13]. The bitemporal method was used to record EOG waveforms.…”

Section: Assessment Of Electro-oculographymentioning

confidence: 99%

Electro-oculography in bilateral optic neuropathy

et al. 2020

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Objective: Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculography. Thirty-seven patients with a clinical diagnosis of bilateral optic neuropathy and 40 control subjects were recruited in this observational, cross-sectional study, carried out at the Neurophysiology unit, Teaching Hospital, Peradeniya, Sri Lanka. Pattern reversal visual evoked potentials, pattern electroretinography and electro-oculography were recorded in all of them. Results: Twenty-four patients (64.9%) had reduced light peak:dark trough ratio values. The median light peak:dark trough ratio ± inter quartile range of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2), (p < 0.001). Median dark trough value was significantly higher in patients compared to the control value. These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region. These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy.

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Comparing Short-Duration Electro-Oculograms with and without Mydriasis in Healthy Subjects

Abstract: Short-duration electro-oculograms allow successful recording, furthermore, the application of mydriasis does not influence the quality of the recording.

Cited by 10 publications

References 25 publications

Linking the Presence of Macular Oedema to Structural and Functional Alterations in Retinitis Pigmentosa

Linking the Presence of Macular Oedema to Structural and Functional Alterations in Retinitis Pigmentosa

Preserved functional and structural integrity of the papillomacular area correlates with better visual acuity in retinitis pigmentosa

Electro-oculography in bilateral optic neuropathy

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