Comparing the Accuracy of ThinPrep Pap Tests and Conventional Papanicolaou Smears on the Basis of the Histologic Diagnosis

Park, In Ae; Lee, Shi Nae; Chae, Seung Wan; Park, Ki Hwa; Kim, Jae Weon; Lee, Hyo Pyo

doi:10.1159/000327859

Cited by 47 publications

(41 citation statements)

References 23 publications

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“…Furthermore, it was possible to obtain higher sensitivity together with significantly reduced ASCUS, 8% with Pap smear to 4% with liquid-based material. The possibility for better diagnostic stringency may correlate with both better specimen adequacy and improved cell morphology, similar to previous studies (22,(25)(26)(27)(28)(29). The occurrence of false-negative reports not only correlates with the morphological quality, but also involves other factors; such as whether the abnormal cells really are present in the sample in a recognizable form, that is, factors merely related to sampling and pre-laboratory handling.…”

Section: Discussionsupporting

confidence: 77%

A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer

Zhu

Norman²,

Elfgren³

et al. 2007

Oncol Rep

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Abstract.The implementation of population-based screening for cervical cancer with Pap smear in the early sixties was set to detect and treat precancerous lesions, hopefully preventing a subsequent invasive cervical cancer. Epidemiological data indicate that organized screening has a major impact on morbidity and mortality from cervical cancer. The limited sensitivity of a single smear necessitates repeated smears in organized program. It is suggested that liquid-based cytology improves the sensitivity. The aim of this split-sample study was to compare ThinPrep liquid-based cytology with conventional Pap smear, relying on a laboratory with long-term experience of the latter. In total, 137 women with atypical Pap smear in population-based cervical screening were enrolled for the splitsample study. The performance of both techniques (ThinPrep liquid-based cytology and conventional Pap smear) were compared and validated by a histological follow-up. Women without representative histological biopsy were excluded from the study. Pap smear had sensitivity for detection of CIN2-3 of 47% compared to 66% for liquid-based material. The concordance of the two sampling techniques with the histological diagnosis was 37% and 53%, respectively, this difference being statistically significant. The proportion of reports on atypical squamous cells of undetermined significance (ASCUS) was significantly less in the liquidbased material, 4.3% compared to 8% of the conventional smears. This improved sensitivity in combination with the possibility to perform reflex testing such as HPV DNA or p16 immunocytochemistry without renewed sampling gives ThinPrep a substantial advantage and makes the liquid-based technique interesting.

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Section: Discussionsupporting

confidence: 77%

A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer

Zhu

Norman²,

Elfgren³

et al. 2007

Oncol Rep

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“…However, the Kappa and the correlation coefficient were not in that high level; this was due to the interesting fact that detection rate of abnormal cells was much higher in the Siriraj-LBC than in the conventional cytology. Our result was comparable with that of Park et al (2001) showing that the results of conventional cytology and LBC exactly agreed in 91.4% of cases.…”

Section: Discussionsupporting

confidence: 88%

Cervical Cancer Prevention by Liquid-Based Cytology in a Low-Resource Setting

Benjapibal¹,

Laiwejpithaya²

2012

Topics on Cervical Cancer With an Advocacy for Prevention

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“…Comparison of unsatisfactory smear rates have varied with some investigators reporting increased rates for liquid based methods (Maksem et al, 2001;Baker et al, 2002, Alves et al, 2004 with some investigators reporting decreased (Park et al, 2001;Baker, 2002) and some, no significant change (Park et al, 2001;Baker, 2002). In our study the number of unsatisfactory smears by CPS was 9 as compared to MLBC which had one unsatisfactory smear with scant squamous cellularity as observed in many studies…”

Section: Discussionmentioning

confidence: 99%

Manual Liquid Based Cytology in Primary Screening for Cervical Cancer - a Cost Effective Preposition for Scarce Resource Settings

Nandini

Nandish²,

Pallavi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Conventional pap smear (CPS) examination has been the mainstay for early detection of cervical cancer. However, its widespread use has not been possible due to the inherent limitations, like presence of obscuring blood and inflammation, reducing its sensitivity considerably. Automated methods in use in developed countries may not be affordable in the developing countries due to paucity of resources. On the other hand, manual liquid based cytology (MLBC) is a technique that is cost effective and improves detection of precursor lesions and specimen adequacy. Therefore the aim of the study was to compare the utility of MLBC with that of CPS in cervical cancer screening. A prospective study of 100 cases through MLBC and CPS was conducted from October 2009 to July 2010, in a Medical College in India, by two independent pathologists and correlated with histopathology (22 cases). Morphological features as seen through MLBC and CPS were compared. Subsequently, all the cases were grouped based on cytological diagnosis according to two methods into 10 groups and a subjective comparison was made. In order to compare the validity of MLBC with CPS in case of major diagnoses, sensitivity and specificity of the two methods were estimated considering histological examination as the gold standard. Increased detection rate with MLBC was 150%. The concordance rate by LBC/histopathology v/s CPS/histopathology was also improved (86% vs 77%) The percentage agreement by the two methods was 68%. MLBC was more sensitive in diagnosis of LSIL and more specific in the diagnosis of inflammation. Thus, MLBC was found to be better than CPS in diagnosis of precursor lesions. It provided better morphology with increased detection of abnormalities and preservation of specimen for cell block and ancillary studies like immunocytochemistry and HPV detection. Therefore, it can be used as alternative strategy for cervical cancer prevention in limited resource settings

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Comparing the Accuracy of ThinPrep Pap Tests and Conventional Papanicolaou Smears on the Basis of the Histologic Diagnosis

Cited by 47 publications

References 23 publications

A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer

A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer

Cervical Cancer Prevention by Liquid-Based Cytology in a Low-Resource Setting

Manual Liquid Based Cytology in Primary Screening for Cervical Cancer - a Cost Effective Preposition for Scarce Resource Settings

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