Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis

Abstract

BackgroundRecently alternative therapies such as the use of diode laser therapy have been introduced for recurrent herpes labial infection. The aim of this study was to evaluate the effectiveness of diode laser for treatment of recurrent herpes labialis.Material and MethodsThis was single-blind randomized clinical trial to evaluate the efficacy of diode laser for the treatment of recurrent herpes labial. In total, 60 patients whit recurrent herpes simplex labialis were selected and randomly divided in to three groups. 20 patients received treatment whit diode laser (at a wavelength of 870 nm, energy density 4.5 j/cm2), 20 patients were treated with acyclovir cream 5%, 20 patients received treatment with laser-off (placebo). The end point was lesions crusting. Data analyzed by Tukey HSD Test and One-way ANOVA (at a significance level of 0.05) in SPSS-20 software.ResultsThe mean length of recovery time (day) in the laser, off laser, and acyclovir groups was 2.20±0.41, 4.30±1.03, and 3.4±1.142, respectively. There is a significant difference between three groups in this regard (P<0.0001). The mean duration of pain (day) was 1.35±0.74, 2.65±1.27, and 2.30±0.92 for laser, off laser, and acyclovir groups, respectively (P<0.0001).ConclusionsTreatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream. Key words:Recurrent herpes labial, Acyclovir, Low level laser therapy.

Antimicrobial photodynamic therapy for recurrent herpes labialis in chronic graft‐versus‐host disease: A case report

“…Moreover, such drugs should be administered many times on consecutive days and may not only interact with other medications but also increase the risk of nephrotoxicity-especially the systemic ones. 7 For immunocompromised patients, however, the treatment is based on systemic drugs for periods between ten days and up to a year. Clinicians should thus monitor the patients since lesions that have not healed within 7-10 days need to be either recultured or biopsied, and sensitivity tests should also be obtained.…”

Protocolo de terapia fotodinâmica e fotobiomodulação no tratamento de herpes simples labial-fase vesicular: relato de dois casos clínicos

“…Um ponto a ser destacado é a divergência de protocolos de tratamento para herpes simples labial quanto aos parâmetros do laser em si, tanto para a TFD como para a terapia de fotobiomodulação (FBM) no período de reparo da lesão, e dos benefícios da associação ou não das duas terapias; esses fatos dificultam a comparação entre estudos. [10][11][12] O que se sabe é que nenhum tratamento a laser é capaz de eliminar completamente o vírus e a sua recorrência. Entretanto, diminui a dor e o intervalo de recorrência, sem causar qualquer efeito secundário, e a TFD reduz a carga viral na fase de vesícula do herpes 3,5 .…”

Effects of Physical Stimulation in the Field of Oral Health

“…At present, many experiments have confirmed the promoting effect of laser on the treatment of oral mucositis. Honarmand et al found that semiconductor laser treatment shortened the recovery time and relieved the pain severity of RHL patients [ 44 ]. Sanchez et al found that compared with acyclovir cream and tablets, laser treatment has fewer side effects and prolongs the recurrence time [ 45 ].…”