2023
DOI: 10.21608/ejhm.2023.284771
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Comparing the efficacy of Micro-needling Alone versus Micro-needling with Topical 5-Fluorouracil in Treating Stable Non-Segmental Vitiligo

Abstract: Background: Vitiligo is a commonly acquired, idiopathic, heritable white macule which increases in diameter with time due to melanocytes loss. Several treatment modalities, ranging from medical to surgical interference, are available. Many studies stated that inducing injury combined with topical 5Fluoro-uracil (5-FU) induces skin re-pigmentation in vitiligo lesions. Microneedling is a reasonably, inexpensive, easy and fast evaluating tool present in outpatient clinics as a trans-dermal drug delivery device fo… Show more

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Cited by 2 publications
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“…Over the years, the World Health Organization (2020) [6] has been including 5-FU in the list of the most important and necessary drugs in the basic health system, given its low cost and efficiency [7]. Additionally, the use of 5-FU has been studied in new approaches, such as 5-FU nanoparticles associated with other molecules [8,9], as well as in applications for treating other diseases, including vitiligo [10]. Thus, it is evident that the side effects of 5-FU must be elucidated in order to improve safety and treatment effectiveness.…”
Section: Introductionmentioning
confidence: 99%
“…Over the years, the World Health Organization (2020) [6] has been including 5-FU in the list of the most important and necessary drugs in the basic health system, given its low cost and efficiency [7]. Additionally, the use of 5-FU has been studied in new approaches, such as 5-FU nanoparticles associated with other molecules [8,9], as well as in applications for treating other diseases, including vitiligo [10]. Thus, it is evident that the side effects of 5-FU must be elucidated in order to improve safety and treatment effectiveness.…”
Section: Introductionmentioning
confidence: 99%