Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection

Razavizadeh, Mohsen; Arj, Abbas; Madani, Maryam; Gilassi, Hamidreza

doi:10.14712/18059694.2020.61

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…The findings of this study indicate that ST could potentially serve as a superior therapeutic approach for managing H. pylori infection compared to the conventional TT regimen [17].…”

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 84%

“…Henceforth, it was deemed a more suitable therapeutic regimen than conventional for initially treating H. pylori infection. Furthermore, this pharmacological treatment protocol demonstrated a decreased incidence of adverse reactions [6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 91%

“…Based on the findings of Razavizadeh et al in 2020 [17], it was observed that sequential treatment regimens exhibited a higher rate of eradication in H. pylori infection compared to standard regimens. Henceforth, it was deemed a more suitable therapeutic regimen than conventional for initially treating H. pylori infection.…”

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori

Tamene,

Mody,

Sadiq

et al. 2023

Cureus

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The Helicobacter pylori infection is a significant issue in global health as it is associated with a range of gastrointestinal disorders and an elevated likelihood of developing stomach cancer. The declining efficacy of standard triple therapy (TT) as the recommended treatment can be attributed to the emergence of drugresistant strains. Sequential therapy (ST) has been recognized as an alternative approach, wherein a combination of proton-pump inhibitor (PPI) and amoxicillin is administered for the initial five days, followed by a combination of PPI, clarithromycin, and metronidazole for the subsequent five days. In this comprehensive systematic review and meta-analysis, we have thoroughly assessed the effectiveness and tolerability of ST as a primary treatment option in comparison to TT for the eradication of H. pylori. The analysis comprised a total of 15 randomized controlled trials, encompassing a sample size of 5,219 patients. The collective findings indicate that ST exhibits promise as it achieves higher rates of eradication. Additionally, it is worth noting that this approach has the potential to yield cost savings and enhance treatment compliance when compared to TT. To summarize, this systematic review and meta-analysis provide evidence that ST is a viable option for the initial treatment of H. pylori eradication. It shows potential benefits compared to the standard TT, especially when there is resistance to clarithromycin. In order to establish ST as the preferred first-line treatment, it is imperative that additional research be conducted to address the aforementioned limitations and thoroughly investigate its long-term efficacy and safety profiles. Nevertheless, it is required that additional research be conducted in order to adequately tackle the constraints of the current studies and solidify its position as a favored treatment alternative. It is also essential to consider ST as a viable approach to improve the rates of H. pylori eradication. This method should be thoroughly examined in clinical practice to gain a deeper understanding of its effectiveness.

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“…The findings of this study indicate that ST could potentially serve as a superior therapeutic approach for managing H. pylori infection compared to the conventional TT regimen [17].…”

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 84%

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 91%

Section: Eradicating the Rate Of St And Ttmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori

Tamene,

Mody,

Sadiq

et al. 2023

Cureus

View full text Add to dashboard Cite

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Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial

Panigrahi

Chouhan

Hallur

et al. 2023

Indian J Gastroenterol

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An Update on Eradication of Helicobacter Pylori in Iran: A Review

Ebrahimi,

Tirgar Fakheri,

Aeeni

et al. 2024

Middle East J Dig Dis

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Background: Helicobacter pylori, the most prevalent infection in the world, has great importance due to being related to peptic ulcer disease, gastric metaplasia, dysplasia, and even gastric adenocarcinoma or mucosa-associated lymphoid tissue (MALT) lymphoma. The standard H. pylori eradication regimen is based on antibiotic susceptibility testing. If susceptibility testing is not available, a standard treatment regimen will be recommended based on records of H. pylori resistance rates to antibiotics in a region or locally proven highly effective regimens (equal to or higher than 90% eradication rate). The aim of this review was to define suitable recommendations for local treatment in different cities of Iran. Methods: This review article consists of randomized controlled trials related to H. pylori eradication in Iran. Data including the kind of therapy, number of patients and per-protocol H. pylori eradication rates were recorded in data gathering forms. Data search was conducted in PubMed and Google Scholar databases from 2018 to December 2023. Results: According to our review of Iranian articles regarding first-line H. pylori eradication regimens, these treatment protocols could be recommended: Bismuth-clarithromycin quadruple therapy in Ardabil, bismuth-clarithromycin quadruple therapy with probiotics in Birjand, standard triple therapy in Ilam, bismuth quadruple therapy or bismuth triple therapy or concomitant regimen in Sari, sequential therapy in Tehran and bismuth quadruple therapy in Yazd. These regimes can be extended to other regions that have a similar situation. According to the reports of Iranian researchers, a quinolone-containing regimen (levofloxacin preferred) is recommended for second-line eradication therapy. Conclusion: Various H. pylori eradication regimens can be used as first-line therapy; however, choices for second-line therapy are limited. We recommend the quinolone-containing regimens as the preferred second-line therapy.

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Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection

Cited by 3 publications

References 33 publications

Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori

Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori

Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial

An Update on Eradication of Helicobacter Pylori in Iran: A Review

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