Comparing the eighth and the seventh editions of the American Joint Committee on Cancer staging system and the Brigham and Women's Hospital alternative staging system for cutaneous squamous cell carcinoma: Implications for clinical practice

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

“…0.1 mm in diameter, may be more concerning in cutaneous SCC, especially when present with other high-risk features. 23,24 Most cancers with perineural invasion are asymptomatic (60%). Signs and symptoms approached with a high index of suspicion should include the following: pain or burning (28%), anesthesia or paresthesia (25%), facial paralysis (22%), diplopia or blurred vision (17%), decreased corneal reflex (4.2%), jugular foramen syndrome (1.4%), and trismus (1.4%).…”

Comment on `The detection rate of human papillomavirus in well‐differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' ‐ reply from authors

“…Notably, the new eighth American Joint Committee on Cancer classification of cutaneous SCC (cSCC) distinguishes between cSCC arising on sunexposed sites from those arising on non-sun-exposed sites. 3 Moreover, peculiar clinical and dermatoscopic differences between the two tumours further support the concept that they represent different entities. This also explains why we did not select our cases based on strict histopathological criteria, but based on the context in which the tumours developed (i.e.…”

High-Risk Nonmelanoma Skin Cancers: Identification, Management, and Reconstruction

“…16 Similarly, Canueto et al found a significant association between tumor location on the ear or lip and disease-specific poor outcome. 6 A systematic review and meta-analysis of cSCC risk factors found that location on the lip or ear was associated with metastasis and disease-specific death, but not recurrence. 12 As mentioned above, the NCCN deems any BCC in the area of the central face, eyelids, eyebrows, periorbital skin, nose, lips, chin, mandible, preauricular and postauricular skin/sulci, temple, or ear as high risk.…”

“…3 Studies comparing the two staging classifications have found AJCC 8 to be more distinctive (outcomes differ among staging categories), monotonous (outcomes worsen as stage increases), and homogenous (outcomes similar within staging categories) than AJCC 7. 6,7 Conversely to AJCC 8, the BWH system was developed with the aim of prognostically stratifying AJCC 7 stage T2. This system continues to solely utilize high-risk factors to differentiate tumors.…”

“…8 Studies have shown BWH to have significant overlap with AJCC 8 without a clear preference for one versus the other. 6 Roscher et al directly compared multiple staging systems (AJCC 7, AJCC 8, BWH, Breuninger) for cSCC using a population-based, nested case-control study and showed AJCC 8 and BWH systems performed better than AJCC 7. 9 A formal staging system for BCC does not exist.…”