Comparing the needs and preferences of patients with moderate and severe dry eye symptoms across four countries

Messmer, Elisabeth M.; Chan, Colin; Asbell, Penny A.; Johnson, Gary R.; Sloesen, Brigitte; Cook, Nigel S.

doi:10.1136/bmjophth-2019-000360

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…Our findings support past literature demonstrating that burning/stinging sensation was the most important consideration for all patients [39,40] and indicate that mitigating burning/stinging sensation could potentially increase patient satisfaction and medication adherence. We also found that patients did not consider vision blurring a major concern.…”

Section: Discussionsupporting

confidence: 90%

Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects

Özdemir

Yeo

Lee

et al. 2022

Patient

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ObjectivesThe side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and blurring) are important to patients compared to medication benefits or costs. Methods Patients diagnosed with DED were recruited at a referral eye center in Singapore (n = 139). This study utilized a Discrete Choice Experiment where patients were presented with 10 choice tasks where they were asked to choose between their current medication (or no medication), and two hypothetical medications that varied based on five attributes: duration of burning/stinging, duration of blurring, time to medication effectiveness, medication frequency, and out-of-pocket cost. The main outcomes were relative attribute importance and predicted uptake. Results Latent class logistic regressions found two groups with distinct preferences. For both classes, duration of burning/ stinging (Class 1 = 23%, Class 2 = 29%) and cost (Class 1 = 24%, Class 2 = 27%) were the most important attributes while duration of blurring (Class 1 = 15%, Class 2 = 9%) was the least important. The predicted uptake of a medication increased 18 percentage-points when burning/stinging duration decreased from 2 h to a few minutes. The predicted uptake for new medications was lowest for those on medication with well-controlled symptoms and highest for those who were not on medication and could not control their symptoms effectively. Conclusion This study showed that duration of burning/stinging was an important factor when choosing medications. Incorporating patient preferences in medication decisions can potentially improve patient acceptance of a treatment regimen.

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Section: Discussionsupporting

confidence: 90%

Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects

Özdemir

Yeo

Lee

et al. 2022

Patient

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“…Further insights from this study concerning the differential outcomes of moderate versus severe DED, differences between countries, and results of a QoL assessment will be reported in a separate manuscript 29…”

Section: Resultsmentioning

confidence: 98%

Defining the needs and preferences of patients with dry eye disease

et al. 2019

Self Cite

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ObjectiveDry eye disease is a multifactorial chronic disease, leading to ocular discomfort and visual disturbance with a substantial impact on quality of life. Therefore, the patient’s perspective should be taken into account early in the drug development process. We have developed a step-by-step methodology based on the self-explicated conjoint approach to assess the needs and preferences of patients with moderate-to-severe dry eye disease.Methods and AnalysisFollowing a literature review and social media listening (step 0), qualitative phone call interviews were conducted with 12 patients (step 1). Patients’ responses underwent content analysis and were coded, quantified and displayed as charts. Based on the emerging trends and attributes identified as relevant in steps 0 and 1, a quantitative online questionnaire was designed and conducted with 160 patients across four countries (step 2).ResultsThe online questionnaire was rated as easy/very easy to understand by 60% of respondents, 62% rated the survey as easy/very easy to complete and 71% rated it as interesting/very interesting. Treatment satisfaction was the most important aspect for patients, and the three most relevant attributes were as follows (with the most important indexed to 100%): ‘treatment effectiveness on symptoms of dry eyes’ (100%), ‘frequency of treatment use’ (96%) and ‘how the treatment works’ (95%).ConclusionOur methodology was well received by patients, and the results will help inform future clinical trial development and discussions with health technology assessment bodies and regulators on unmet needs and product attributes that are of most value to patients with dry eye disease.

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“…A number of methods are employed for assessing patient experiences, often using qualitative interviews and quantitative questionnaires [18,19]. A recent addition to the toolkit is social media listening, which has been applied successfully in a range of eye conditions including presbyopia to identify topics patients consider important in peer-to-peer discussions [9,20,21].…”

Section: Introductionmentioning

confidence: 99%

Living with presbyopia: experiences from a virtual roundtable dialogue among impacted individuals and healthcare professionals

Brujic

Kruger²,

Todd

et al. 2022

BMC Ophthalmol

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Background Presbyopia is a common progressive vision disorder characterised by an inability to focus on near objects. The emergence of newer treatment options in addition to spectacles or contact lenses highlights the importance of assessing patient/user preferences. Methods People with presbyopia and healthcare professionals (HCPs) took part in a moderated, structured discussion of specific questions on a virtual advisory-board platform. The objective was to better understand unmet needs and the experience of living with the condition. Closed and open questions were included. Results Nine individuals (age 40 to 70 years) with presbyopia participated, from Australia, China, France, Italy, Ireland, Japan and the US. One ophthalmologist and one optometrist represented the perspective of HCPs. Over two weeks, 621 posts were entered on the platform. There was widespread agreement that the often stated association between age and presbyopia was unfortunate. Some participants had developed presbyopia at 30–45 years of age. What is more, the association with age was seen as implying a natural process, reducing the incentive to treat. Instead there was a call for an action-oriented view of presbyopia as a condition which may be effectively treated in the future. All participants experienced dealing with presbyopia as burdensome, affecting quality of life to varying degrees. When considering new treatments, convenience was the most important factor. The option to administer drops when needed was considered favourable, but short-acting treatments may not reduce inconvenience compared with spectacles. Participants viewed a therapy that targets the underlying cause of the condition favourably compared with symptomatic treatment. Side effects would severely reduce the appeal of drops. For clinical trials in presbyopia, patient-reported outcomes should be mandatory and need adequately to capture quality of life. Studies in presbyopia must be designed to minimise the inconvenience to participants in order to counter the risk of high drop-out rates. Conclusions The interactive format provided insights into living with presbyopia, particularly the negative impact on quality of life, subjects’ openness to new therapies, and the need to move away from considering the condition an unavoidable and intractable consequence of ageing.

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Comparing the needs and preferences of patients with moderate and severe dry eye symptoms across four countries

Cited by 13 publications

References 25 publications

Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects

Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects

Defining the needs and preferences of patients with dry eye disease

Living with presbyopia: experiences from a virtual roundtable dialogue among impacted individuals and healthcare professionals

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