Comparing the Surface Chemical Properties and the Effect of Salts on the Cloud Point of a Conventional Nonionic Surfactant, Octoxynol 9 (Triton X-100), and of Its Oligomer, Tyloxapol (Triton WR-1339)

Schott, Hans

doi:10.1006/jcis.1998.5721

Cited by 55 publications

(50 citation statements)

References 24 publications

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“…WR-1339 essentially is an oligomer of TrX with very similar, although not completely identical, characteristics [22]. In our study presented here, we confirmed that TrX had comparable growth-inhibitory effects on experimental tumors ( fig.…”

Section: Discussionsupporting

confidence: 79%

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Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

et al. 2004

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A cross-linked form of the detergent Triton X-100, called Triton WR-1339, has been shown to reduce the spread of tumor cells in laboratory animals. However, some of these effects were controversial, probably due to the use of different tumor cell lines and varying sites of injection. In order to better understand these processes, we have used Triton X-100 and performed a molecular analysis of its growth-inhibitory function. Using the T24 bladder carcinoma cell line, we have shown that treatment of cells with this detergent caused a potent antiproliferative effect resulting from the downregulation of the key cell cycle regulators, the cyclin-dependent kinases (CDKs). CDK activity was lost due to a twofold effect, the increased expression of the CDK inhibitors p21^Cip1 and p27^Kip1 in combination with the reduced expression of cyclin A, a regulatory CDK subunit that is essential for CDK function. Taken together, our results provide a molecular basis for the antiproliferative effects of the Triton detergent, namely its differential effects on various parts of the cell cycle machinery.

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Section: Discussionsupporting

confidence: 79%

“…WR-1339 (tyloxapol) is a heptamer of TrX with cross-linking between the benzene rings. Both compounds are non-ionic, comparatively mild non-denaturing detergents [22].…”

Section: Source Of Reagentsmentioning

confidence: 99%

Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

et al. 2004

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“…[4][5][6][7][8][9][10][11][12] These studies have demonstrated how the critical micellar concentration (cmc), surface and interfacial tension, the size and shape of surfactant aggregates, and cloud points are affected by temperature, salt type and concentration, and the size of ethoxylate headgroups. The main drawback in these studies is that impure samples have been used.…”

Section: Introductionmentioning

confidence: 98%

The Monolayer Structure of the Branched Nonyl Phenol Oxyethylene Glycols at the Air−Water Interface

Green

et al. 2000

J. Phys. Chem. B

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The structure of the monolayers formed by a group of monodisperse nonyl phenol ethoxylates with parasubstituted 1-butylpentyl chains (para-(C 4 H 9 ) 2 CHC 6 H 4 (OC 2 H 4 ) n OH, abbreviated to BNPE n , n ) 4, 8, and 12) at the air-water interface has been determined by surface tension measurements and neutron reflection. The critical micellar concentration (cmc) was found to be 1.1 ( 0.3 × 10 -5 M for BNPE 4 , 4.0 ( 0.3 × 10 -5 M for BNPE 8 and 8.0 ( 0.3 × 10 -5 M for BNPE 12 and the limiting area per molecule (A cmc ) at the cmc to be 46 ( 3, 61 ( 4, and 75 ( 5 Å 2 , respectively. The values of A cmc are almost identical to those obtained from dodecyl ethoxylates (C 12 E n ) for the same size of the headgroups, suggesting that A cmc for these nonionic surfactants is determined by the size of the headgroups and is not affected by the chemical structure of the hydrophobic chains. The thicknesses of the nonyl phenol layers projected onto the surface normal direction were found to be 18 ( 3 Å for BNPE 4 , 19 ( 3 Å for BNPE 8 , and 22 ( 3 Å for BNPE 12 . In all cases they were about twice as thick as the fully extended chain, suggesting a broad distribution of the hydrophobic chain across the layer and hence a strong mixing of the chain with the ethoxylate groups.

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“…The literature [10][11][12] has been reporting the use of some kinds of additives for this purpose, such as a class of compounds known as hydrotropes or hydrotropic agents. Such substances have the ability to increase the solubility of organic compounds that are slightly soluble in water.…”

Section: Introductionmentioning

confidence: 99%

PLURONIC × TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry

Mansur

Barboza

González

et al. 2004

Journal of Colloid and Interface Science

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Comparing the Surface Chemical Properties and the Effect of Salts on the Cloud Point of a Conventional Nonionic Surfactant, Octoxynol 9 (Triton X-100), and of Its Oligomer, Tyloxapol (Triton WR-1339)

Cited by 55 publications

References 24 publications

Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

The Monolayer Structure of the Branched Nonyl Phenol Oxyethylene Glycols at the Air−Water Interface

PLURONIC × TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry

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