Comparison among Conventional 4 L Polyethylene Glycol, Split Method of 4 L Polyethylene Glycol and Combination of 2 L Polyethylene Glycol and Sodium Phosphate Solution for Colonoscopy Preparation

Jo, So Young; Kim, Nayoung; Lee, Jung Won; Lim, Ji Hwan; Choi, Chanjoong; Chon, Ilyoung; Kil, Ho; Min, Bo Young; Byoun, Young Sang; Lee, Ban Seok; Jang, Sung‐Yeon; Park, Hyun Kyung; Jo, Hyun Jin; Shin, Cheol Min; Lee, Sang Hyup; Park, Young Soo; Hwang, Jin Hyeok; Kim, Jin Wook; Jeong, Sook Hyang; Lee, Dong Hoon

doi:10.4166/kjg.2012.59.6.414

Cited by 2 publications

(2 citation statements)

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“… 13 , 28 – 30 To date, however, few studies have investigated combinations of 2 different bowel-cleansing agents. 22 , 31 Our hypothesis was that the combination of 2 different regimens at half dosage could augment the strength of each regimen while also reducing side effects. In this prospective, randomized, single-blind, phase II study, we evaluated the efficacy, tolerability, and side effects of 4 different combination regimens: PMC-PEG-DP, PMC-PEG-SD, PMC-NaP-DP, and PMC-NaP-SD.…”

Section: Discussionmentioning

confidence: 99%

“…Although 2-L PEG with ascorbic acid has been included as a valid alternative to 4-L PEG in the ESGE guideline, several studies have noted the relatively low quality of right colon preparation as a drawback of 2-L PEG with ascorbic acid. 23 , 31 Accordingly, we were concerned that using agents at half dosages could possibly result in suboptimal bowel preparation; however, excellent results were achieved in all segments of the colon, including the right colon. It is likely that the combination of PMC and PEG or NaP might be synergistic, potentially conferring better efficacy for bowel preparation than any of the individual agents.…”

Section: Discussionmentioning

confidence: 99%

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Phase II Randomized Controlled Trial of Combined Oral laxatives Medication for BOwel PREParation (COMBO-PREP study)

et al. 2016

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The combination of different laxatives at reduced volumes may benefit patients by enhancing efficacy for bowel cleansing and increasing tolerability. However, evidence regarding combined preparations is scarce. This study evaluated whether the combined preparations are associated with enhanced efficacy and tolerability.This randomized phase II study had a single-blind, parallel-arm design.Between December 2013 and September 2014, consecutive patients aged between 20 and 65 years and who required diagnostic colonoscopies were considered for inclusion. Patients were randomly allocated into 4 arms: sodium picosulfate and magnesium citrate (PMC) and polyethylene glycol (PEG) with ascorbic acid in a day-prior (PMC-PEG-DP), PMC and oral sodium phosphate (NaP) in a day-prior (PMC-NaP-DP), PMC and PEG with ascorbic acid in a split-dose (PMC-PEG-SD), and PMC and oral NaP in a split-dose (PMC-NaP-SD). Primary endpoint was the Aronchick scale, and Ottawa scale results by colon segment, patients’ adverse gastrointestinal symptoms, and willingness to reuse the same agents were also recorded. Successful bowel preparation was defined as an “excellent” or “good” score on the Aronchick scale.A total of 236 patients were randomized and 229 patients received the planned colonoscopy. The rates of successful bowel preparation in the PMC-PEG-DP, PMC-NaP-DP, PMC-PEG-SD, and PMC-NaP-SD were 82.5%, 64.4%, 100%, and 100%, respectively. Excluding the failed PMC-NaP-DP group, all groups showed satisfactory rates of successful bowel preparation, and the mean Ottawa scores were significantly better in the PMC-PEG-SD and PMC-NaP-SD groups than in the PMC-PEG-DP group (P < 0.0001). The PMC-PEG-DP, PMC-NaP-DP, PMC-PEG-SD, and PMC-NaP-SD groups were similar in terms of rates of adverse gastrointestinal symptoms reported on a 5-point scale (P = 0.40) and willingness to reuse the same combined preparations (P = 0.55).PMC-PEG in a day-prior or split-dose and PMC-NaP in a split-dose were efficient and tolerable bowel preparations for colonoscopy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phase II Randomized Controlled Trial of Combined Oral laxatives Medication for BOwel PREParation (COMBO-PREP study)

et al. 2016

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Sex difference in bowel preparation quality and colonoscopy time

Hwang

Shin

Kim

et al. 2021

Korean J Intern Med

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Background/Aims: The length of colon is known to be longer in females than in males. In addition, the morphology of colon cancer is different between males and females. The aim of this study was to investigate sex differences in Boston bowel preparation score (BBPS) and colonoscopy insertion time. Methods: This study retrospectively analyzed medical records and colonoscopy readings of subjects who underwent colonoscopy at Seoul National University Bundang Hospital from March 2015 to April 2018. BPPS was used to evaluate the degree of colon cleanness before colonoscopy. Statistical analysis was performed to compare demographic, clinical, and outcome variables between two groups. Results: The study group consisted of a total of 12,561 patients (6,148 females and 6,413 males). Mean age was 57.8 ± 13.5 years for females and 57.5 ± 13.8 years for males (p = 0.695). Females showed better bowel preparation than males (mean total score: 7.4 ± 1.8 vs. 7.2 ± 1.9, p = 0.001; total score ≥ 6: 5,340 [86.9%] vs. 5,437 [84.8%], p = 0.001; BBPS ≥ 2 for all segments: 5,048 [82.1%] vs. 5,097 [79.5%], p < 0.001). However, cecal intubation time (8.3 ± 6.2 minutes vs. 6.2 ± 6.1 minutes, p < 0.001) and withdrawal time (7.9 ± 3.5 minutes vs. 7.4 ± 3.1 minutes, p < 0.001) were longer in males. Conclusions: There were sex differences in BBPS, cecal intubation time, and withdrawal time for subjects undergoing colonoscopy.

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Comparison among Conventional 4 L Polyethylene Glycol, Split Method of 4 L Polyethylene Glycol and Combination of 2 L Polyethylene Glycol and Sodium Phosphate Solution for Colonoscopy Preparation

Abstract: PEG 4 L showed better result than split method of 4 L PEG or PEG 2 L plus NaP 90 mL in the aspect of bowel preparation quality and safety.

Cited by 2 publications

References 19 publications

Phase II Randomized Controlled Trial of Combined Oral laxatives Medication for BOwel PREParation (COMBO-PREP study)

Phase II Randomized Controlled Trial of Combined Oral laxatives Medication for BOwel PREParation (COMBO-PREP study)

Sex difference in bowel preparation quality and colonoscopy time

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