Comparison between 4‐MV and 6‐MV radiotherapy in T1N0 glottic cancer

Sommat, Kiattisa; Yit, Nelson Ling Fung; Kwok, Li-Lian

doi:10.1002/lary.26067

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Some studies applied elective neck irradiation, and some administrated a bolus in patients with AC involvement. In 14 studies (41.2%) LC rates were not presented for the AC separately [7,8,9,10,11,12,13,14,15,16,17,18,19,20]. These studies only presented p -values, hazard ratios (HR), or odds ratios.…”

Section: Resultsmentioning

confidence: 99%

“…In 23 out of 34 (67.6%) studies in the radiotherapy group, AC involvement did not have a significant impact on LC [5,7,8,9,11,13,14,15,16,17,18,20,34,39,40,41,42,44,46,48,49,51], and in 10 studies (29.4%), it did have a significant impact [10,19,35,36,37,43,45,47,50,52]. One study (2.9%) concluded that the AC was a predictive factor for LC in T1 tumors, but not in T2 tumors [38].…”

Section: Resultsmentioning

confidence: 99%

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Involvement of the Anterior Commissure in Early Glottic Cancer (Tis-T2): A Review of the Literature

Hendriksma

Sjögren

2019

Cancers

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Background: The impact of the anterior commissure (AC) involvement on prognosis in laryngeal cancer remains a topic of discussion with inconsistent results in the literature. This review examines AC involvement as a prognostic factor in patients with early glottic cancer (Tis–T2) treated with radiotherapy or transoral laser microsurgery (TLM). Methods: A systematic literature search was performed. Due to the heterogeneity of the data, no meta-analysis was implemented. Weighted averages were calculated if the appropriate data were extractable. Results: Thirty-four studies on radiotherapy and 23 on TLM fit the inclusion criteria. The majority of studies for both radiotherapy (67.7%) and TLM (75.0%) did not report a significant impact on oncological outcomes. Weighted averages were slightly lower in patients with AC involvement. The two studies that applied a more detailed classification showed a significant impact on the amount of AC involvement. Conclusions: Binary variables (yes/no) for AC involvement lead to inconsistent results. Studies that use more detailed classifications of the AC show that there is a significant impact on the outcome. To further elucidate the role of the AC, detailed stratification of tumors involving the AC need to be investigated in further studies for both treatment modalities.

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