Comparison between Briganti, Partin and MSKCC tools in predicting positive lymph nodes in prostate cancer: a systematic review and meta-analysis

Cimino, Silvia; Reale, Giulio; Castelli, Tommaso; Favilla, Vincenzo; Giardina, Raimondo; Russo, Giorgio Ivan; Privitera, Salvatore; Morgia, Giuseppe

doi:10.1080/21681805.2017.1332680

Cited by 68 publications

(43 citation statements)

References 31 publications

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“…The MSKCC nomogram showed an AUC of 0.77 similar to the literature (0.78) in a recent meta-analysis (25). With an AUC of 0.67 in our analysis, the updated Partin tables were slightly less accurate than the AUCs in prior cohorts (0.77 and 0.80) (25)(26)(27). The reduced accuracy might be a result of our patient cohort including only high-risk patients, as Partin tables are most powerful in low-and intermediate-risk PC (5,26).…”

Section: Discussionsupporting

confidence: 79%

“…In our study, the performances of the MSKCC nomogram and Partin tables were comparable to literature. The MSKCC nomogram showed an AUC of 0.77 similar to the literature (0.78) in a recent meta-analysis (25). With an AUC of 0.67 in our analysis, the updated Partin tables were slightly less accurate than the AUCs in prior cohorts (0.77 and 0.80) (25)(26)(27).…”

Section: Discussionsupporting

confidence: 73%

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One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

et al. 2018

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Our aim was to assess the diagnostic potential of 1-stop-shop prostate-specific membrane antigen ligand (Ga-PSMA-11) PET/MRI compared with preoperative staging nomograms in patients with high-risk prostate cancer. A total of 102 patients underwentGa-PSMA-11 PET/MRI before intended radical prostatectomy with lymph node dissection. Preoperative variables determined the probabilities for lymph node metastases (LNM), extracapsular extension (ECE), and seminal vesical involvement (SVI) using the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram and Partin tables. Receiver-operating-characteristic analyses were performed to determine best discriminatory cutoffs. On a cohort basis, positivity rates of imaging and nomograms were compared with pathologic prevalence. On a patient basis, sensitivity, specificity, and area under the curves were calculated. Finally, the full concordance of each method to postoperative T and N stage was determined. Seventy-three patients were finally analyzed. On a cohort basis, the MSKCC nomogram (39.7%) positivity rate was most concordant with pathologic prevalence for LNM (34.3%) compared with Partin tables (14.1%) and imaging (20.6%). Prevalence of ECE (72.6%) was best predicted by MSKCC nomograms and imaging (83.6% each), compared with Partin tables (38.4%). For prevalence of SVI (45.2%), imaging (47.9%) performed superior to MSKCC (37.6%) and Partin tables (19.3%). On a patient basis, AUCs for LNM, ECE, and SVI did not differ significantly between tests ( > 0.05). Imaging revealed a high specificity (100%) for LNM and a sensitivity (60%) comparable to the MSKCC nomogram (68%) and Partin tables (60%). For ECE, imaging revealed the highest sensitivity (94.3%) compared with the MSKCC nomogram (66%) and Partin tables (71.1%). For SVI, sensitivity and specificity of imaging and the MSKCC nomogram were comparable (81.5% and 80% vs. 87.9% and 75%). The rate of concordance to the final pTN stage was 60.3% for imaging, 52.1% for the MSKCC nomogram, and 39.7% for Partin tables. In our analysis, preoperative 1-stop-shopGa-PSMA-11 PET/MRI performs at least equally for T and N stage prediction compared with nomograms in high-risk prostate cancer patients. Despite an improved prediction of the full final stage and the yield of additional anatomic information, the use ofGa-PSMA-11 PET/MRI warrants further prospective evaluation.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 73%

One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

et al. 2018

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“…If lymph node biopsy is indicated according to various nomograms, absolutely lymph node dissection should be performed so that the patient can be correctly evaluated and multi-modal treatment can be performed in case of need. [7] The Tugcu Bakırkoy technique allows for dissection of the pelvic lymph node with less morbidity than other techniques and with superior cosmetic, and equivalent oncological results relative to other methods. This technique does not affect the intestines and there is no need to intervene intraabdominal adhesions developed due to previous surgery.…”

Section: Discussionmentioning

confidence: 99%

Robotic perineal radical prostatectomy and robotic pelvic lymph node dissection via a perineal approach: The Tugcu Bakirkoy Technique

Tuğcu¹,

Akça²,

Şimşek³

et al. 2018

Turkish Journal of Urology

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Objective: To describe The Tugcu Bakirkoy robotic perineal radical prostatectomy and pelvic lymph node dissection technique, and present the results of seven patients. Material and methods:We performed seven robotic perineal radical prostatectomy and pelvic lymph node dissection operation using Da Vinci Xi HD Surgical System (Intuitive Surgical, Inc., Sunnyvale, California, USA) on single Gel-port platform. The operation is completed in 4 stages: stage 1 open perineal dissection and gel port placement, stage 2 robotic perineal radical prostatectomy, stage 3 robotic pelvic lymph node dissection, stage 4 vesico-urethral anastomosis. In addition to describing the operation technique step by step, we aimed to present the perioperative and postoperative findings of the seven patients who underwent The Tugcu Bakirkoy Technique.Results: All operations were successfully completed without any complications in fully the robotic procedure by a single surgeon. Demographic data of the patients were as follows: Mean age (62.1±8 years), mean body mass index (28.2±0.7 kg/m 2 ), mean prostate specific antigen value (10.7±3 ng/mL), and mean prostate volume (64.2±15.3 cc). Mean operative time (184.1±20.2 mins), blood loss (64.2±15.3 cc), hospitalization time (2.1±0.6 days), and time to withdrawal of the urethral catheter (7.8±0.8 days) were also estimated. According to the pathology results, lymph node metastasis was detected in 3 patients while the surgical margin was positive in one. Conclusion:We demonstrated for the first time that a new The Tugcu Bakirkoy robotic perineal radical prostatectomy technique which was previously tested in a cadaveric model, can be safely applied for the first time in vivo, and presented our results. On the basis of this, for problems that can not be overcome by traditional methods, this method is a good alternative as a way out. In this regard, it is necessary to carry out advanced studies so that this method can be applied to daily practice.

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“…This lack of evidence, combined with the perceived increased morbidity of the added procedure, is driving a decline in the practice of lymphadenectomy, except in the presence of high-grade or high-volume disease. Current guidelines recommend treatment of the lymphatic drainage at the time of radiotherapy or radical prostatectomy if the risk of nodal metastasis exceeds 5% by commonly used nomograms such as the Briganti, Partin, and Memorial Sloan Kettering Cancer Center nomograms (usually representing intermediate-and highrisk PC) (67)(68)(69). Guidelines also recommend that primary PC patients with a higher risk profile should not be spared ePLND irrespective of negative findings on imaging (20).…”

Section: Comparison Of Psma-guided Primary Lymph Node Dissection To Smentioning

confidence: 99%

Prostate-Specific Membrane Antigen–Guided Surgery

et al. 2019

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Since its introduction to the diagnostic pathway for prostate cancer management, prostate-specific membrane antigen (PSMA)-ligand PET has demonstrated great potential. PSMA-ligand imaging is increasingly influencing therapeutic decision making, although its impact on patient outcomes still needs to be defined. One relatively new application, enabled through chemical and engineering efforts, is PSMA-guided surgery. This review highlights the potential of PSMA-guided surgery and discusses its implications in lymph node dissection in primary and recurrent prostate cancer.

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Comparison between Briganti, Partin and MSKCC tools in predicting positive lymph nodes in prostate cancer: a systematic review and meta-analysis

Abstract: The accuracy of Briganti, Partin and MSKCC was similar in predicting the presence of LNI. Based on these results, patients and clinicians may use any of these nomograms without significant advantages.

Cited by 68 publications

References 31 publications

One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

Robotic perineal radical prostatectomy and robotic pelvic lymph node dissection via a perineal approach: The Tugcu Bakirkoy Technique

Prostate-Specific Membrane Antigen–Guided Surgery

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Comparison between Briganti, Partin and MSKCC tools in predicting positive lymph nodes in prostate cancer: a systematic review and meta-analysis

Abstract: The accuracy of Briganti, Partin and MSKCC was similar in predicting the presence of LNI. Based on these results, patients and clinicians may use any of these nomograms without significant advantages.

Cited by 68 publications

References 31 publications

One-Stop-Shop Whole-Body 68Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

One-Stop-Shop Whole-Body 68Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

Robotic perineal radical prostatectomy and robotic pelvic lymph node dissection via a perineal approach: The Tugcu Bakirkoy Technique

Prostate-Specific Membrane Antigen–Guided Surgery

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Product

Resources

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One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer

One-Stop-Shop Whole-Body ⁶⁸Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer