Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

Stefańska, Anna; Sypniewska, Grażyna; Blaszkiewicz, B; Ponikowska, Irena; Cwiklinska-Jurkowska, Malgorzata

doi:10.1016/j.clinbiochem.2010.12.002

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…In addition, A-FABP might have proinflammatory properties related to lipopolysaccharide-induced inflammation by forming a positive feedback loop with the JNK/c-Jun signaling cascade 53 , which is involved in impaired insulin action. Several studies showed correlation between A-FABP and proinflammatory factors, like C-reactive protein (CRP), and their similar importance in predicting insulin resistance 54,55 .…”

Section: Adipocyte Fatty Acid Binding Protein (A-fabp)mentioning

confidence: 99%

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Park

Sweeney

2015

Critical Reviews in Clinical Laboratory Sciences

139

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Insulin resistance in insulin target tissues including liver, skeletal muscle and adipose tissue is an early step in the progression towards type 2 diabetes. Accurate diagnostic parameters reflective of insulin resistance are essential. Longstanding tests for fasting blood glucose and HbA1c are useful and although the hyperinsulinemic euglycemic clamp remains a "gold standard" for accurately determining insulin resistance, it cannot be implemented on a routine basis. The study of adipokines, and more recently myokines and hepatokines, as potential biomarkers for insulin sensitivity is now an attractive and relatively straightforward approach. This review discusses potential biomarkers including adiponectin, RBP4, chemerin, A-FABP, FGF21, fetuin-A, myostatin, IL-6, and irisin, all of which may play significant roles in determining insulin sensitivity. We also review potential future directions of new biological markers for measuring insulin resistance, including metabolomics and gut microbiome. Collectively, these approaches will provide clinicians with the tools for more accurate, and perhaps personalized, diagnosis of insulin resistance.

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Section: Adipocyte Fatty Acid Binding Protein (A-fabp)mentioning

confidence: 99%

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Park

Sweeney

2015

Critical Reviews in Clinical Laboratory Sciences

139

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“…Similarly increased CRP levels (2.54 mmol/l) (ref. 9 ) in females with metabolic syndrome were reported by Stefanska 9 . Females should have higher CRP and aFABP levels than males 8 .…”

Section: Discussionmentioning

confidence: 99%

“…The logistic regression models assessed the potential use of these markers as tools for estimating the probability of the development of metabolic syndrome. Concentration of aFABP is equivalent with CRP and both have a reasonable diagnostic potential 9 . In accordance with these data, our logistic regression models also showed a slight association of aFABP and CRP with BMI, the QUICKI and triglycerides, related to the development of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

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Adipocyte Fatty Acid Binding Protein and C-Reactive Protein Levels as Indicators of Insulin Resistance Development

Horáková

Pastucha²,

Stejskal³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Adipocyte fatty acid-binding protein (aFABP) has recently been identified as a potential circulating marker for metabolic syndrome. C-reactive protein (CRP), a sensitive marker of inflammation, is increased in individuals with diabetes and metabolic syndrome due to the development of subclinical inflammation. The study uses logistic regression models to analyze the relations between aFABP and CRP along with other parameters of insulin resistance. The objective was to investigate the potential use of aFABP and CRP levels as tools in the diagnosis of the metabolic syndrome.Methods and results. The following groups were studied: healthy individuals (A, n=122), obese ind1ividuals (B, n=213) and patients diagnosed with metabolic syndrome (C, n=79). Obese persons in Group B had parameters suggestive of early insulin resistance: hypertension, hyperglycaemia, QUICKI (0.305) and higher aFABP levels as compared with the healthy subjects. Group C individuals were diagnosed with metabolic syndrome, as evidenced by the QUICKI markers for insulin resistance (0.293), high aFABP levels (35.3 mg/l). CRP concentrations were lowest in Group A healthy individuals (0.67 mg/l), higher in Group B obese subjects (2.65 mg/l) and highest in Group C patients with metabolic syndrome (3.62 mg/l). Logistic regression models showed an association of aFABP and CRP with BMI (OR 1.12 and 1.39, compared Group A vs C). An association of aFABP and CRP with the QUICKI index showed OR 1.48 and 1.37 (Group A vs C); with triglyceride levels showed OR 1.68 and 1.52 (Group A vs C). An association of aFABP and CRP with glycaemia showed OR 1.48 and 1.51 (Group A vs C), with insulinaemia showed OR 1.44 and 1.38 (Group A vs C) respectively.Conclusions. AFABP levels were higher in obese individuals and highest in those with metabolic syndrome. CRP concentrations were increased in obese persons whereas individuals with metabolic syndrome were found to have high-risk CRP levels. Logistic regression models showed an association of aFABP and CRP with BMI as well as an association of aFABP and CRP with parameters of insulin resistance, namely the QUICKI index, triglyceride levels, glycaemia and insulinaemia. Both methods are of diagnostic benefit for predicting metabolic syndrome, especially in previously untreated patients.

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“…In particular, CRP levels are found to be elevated in visceral adipose tissue (Saijo et al, 2004). In diagnostics, CRP is used as a marker of inflammation (Stefanska et al, 2011). Inflammation, on the other hand, is crucial in cognitive decline, AD, and vascular dementia.…”

Section: C-reactive Protein (Crp)mentioning

confidence: 99%

Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology

Pichiah

Sankarganesh

Arunachalam

et al. 2020

Front. Aging Neurosci.

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The global incidence of Alzheimer's disease (AD) is on the rise with the increase in obesity and metabolic disease epidemic. Obesity is co-morbid with the increase in mass of adipose tissue, which secretes numerous molecules that are biologically important. Obesity and its associated conditions are perhaps involved in the causative pathway of AD. Immunologically important cytokines such as IL-1β, IL-10, and IL-18, which are released by adipose tissue, are also found to be associated with AD. Besides, the expression of IL-6, IFNγ, and TNF alpha are also associated with AD. Ang-I and Ang-II are found to mediate the progression of AD. Complement factors B, C4b, and H are differentially expressed in AD. Overall, several adipocyte-derived cytokines are found to be dysregulated in AD, and their role in AD remains to be studied. The induction of autophagy is a very promising strategy in the treatment of AD. A variety of adipose-derived molecules have been shown to modulate autophagy. However, very little literature is available on the role of adipose-derived molecules in inducing autophagy in microglial cells of AD. Understanding the role of adipose-derived molecules in the development of AD, especially in the induction of autophagy, would open up new avenues in devising strategies for the treatment of AD.

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Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

Cited by 10 publications

References 10 publications

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Adipocyte Fatty Acid Binding Protein and C-Reactive Protein Levels as Indicators of Insulin Resistance Development

Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology

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