Comparison Between Concentrated Bone Marrow Aspirate and Corticoid in Gluteal Tendinopathy

Abstract

Objective: To compare bone marrow aspirate concentrate (BMAC) with the standard treatment for gluteal tendinopathies. Methods: 48 patients diagnosed with gluteal tendinopathy at a university hospital were selected by a randomized clinical trial and divided into two groups: (G1) bone marrow aspirate concentrate and (G2) corticosteroid injections. Results: 40 of the 48 selected patients were monitored for six months and both groups showed better scores. Visual analog scale (VAS) scores and Lequesne index were statistically significant higher in patients submitted to BMAC treatment when compared to standard treatment. Both groups improved their quality of life, without statistically significant difference. Conclusion: BMAC constitutes an alternative to gluteal tendinopathy standard treatment, proving to be a safe technique with promising results when combined with multidisciplinary team behavioral therapy. Level of Evidence II, Randomized Clinical Trial.

Cell therapy efficacy and safety in treating tendon disorders: a systemic review of clinical studies

“…There was only one study on gluteal tendinopathy, in which they used BMC in the intervention group and corticosteroid in the control group [ 40 ]. This technique was safe and effective in significantly reducing the VAS score and Lequesne score compared to the control group.…”

“…After removing duplicates, 2543 studies were screened by title and abstracts. Subsequently, the remaining 262 articles were evaluated by full-text for eligibility, and 22 were selected [14,15,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. In terms of the title and abstract screening (κ = 0.89; 95% CI:, 0.86 -0.92), as well as the full text (κ = 0.85; 95% CI,: 0.81 -0.89) there was excellent agreement across reviewers.…”

“…All the studies in this review demonstrated the potential effect of cell therapy in tendon disorder treatment. Although some of the articles reported the beneficial impact of cell injection on tendinopathies and the superiority of the cell injected group compared to controls [ 14 , 26 , 28 , 29 , 32 , 40 ], other RCTs and studies with a control group showed no improvement in outcomes in the treatment group compared to controls [ 15 , 34 , 39 ]. However, the procedure satisfied a high rate of patients [ 32 , 38 ].…”

“…Studies used various types of cells from diverse sources, bone marrow, adipose tissue, or skin. Many studies in this review administered BMC [ 14 , 15 , 25 , 32 , 33 , 37 , 38 , 40 , 42 , 43 ], which contains MSCs, but also contains other biologic factors and platelets. Furthermore, an unknown number of cells were injected.…”

The effect of corticosteroid injection in the treatment of greater trochanter pain syndrome: a systematic review and meta-analysis of randomized controlled trials

“…Then 161 studies were excluded after titles and abstracts screened, and 17 studies were left for full-text screening. Due to case report [ 22 ], duplicate [ 23 ], no required data [ 24 – 27 ], and study design [ 28 – 30 ], 9 studies were excluded. Finally, 8 RCTs [ 31 – 38 ]were included in our meta-analysis, which included a total of 764 participants.…”