2024
DOI: 10.3389/fbrio.2024.1440288
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Comparison between metagenomic next-generation sequencing in bronchoalveolar lavage fluid and blood for the diagnostic performance of respiratory tract infection: a meta-analysis

Zhou Sun,
Guofu Liang,
Yulin Niu

Abstract: ObjectiveMetagenomic next-generation sequencing (mNGS) is emerging to be pivotal in infectious disease diagnosis, particularly in pulmonary infection. However, the utility of bronchoalveolar lavage fluid (BALF) versus blood mNGS remains controversial. Therefore, the current meta-analysis summarized the previous studies regarding BALF or blood mNGS in pulmonary infection, aiming to comprehensively compare the diagnostic efficiency between them.MethodsStudies reporting paired BALF and blood mNGS data for pulmona… Show more

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