Comparison Between Renal Parenchymal Sonographic Volume, Renal Parenchymal Urographic Area, Glomerular Filtration Rate and Renal Plasma Flow in Children

Abstract

A comparison of renal size, expressed as ultrasonographic renal parenchymal volume and urographic renal parenchymal area, and renal function, measured as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), was made in two groups of children: (1) 21 patients with normal urograms and no signs of current disease and (2) 26 children with recurrent urinary tract infections or asymptomatic bacteriuria. Renal parenchymal volume was calculated using a water delay ultrasonographic device (Octoson). Renal parenchymal area was measured urographically. GFR and ERPF were determined from the clearances of inulin and PAH, respectively. In both groups a good correlation was found between both GFR and ERPF and total renal parenchymal volume as well as renal parenchymal area. The determination of renal parenchymal volume could possibly replace the determination of GFR and ERPF in healthy children and in children with urinary tract infections with normal and abnormal urograms.

Increased kidney growth in formula-fed versus breast-fed healthy infants

“…This may be due to a relatively low number of infants in the partially breast and fully formula-fed groups or the uncertainty of the method of clearance estimation. Other studies have shown that GFR is positively associated with kidney size [31,32,33,34], and both increased GFR and kidney size have been found in young rats on a high-protein diet [1].…”

Correlation of kidney size with kidney function and anthropometric parameters in healthy subjects and patients with chronic kidney diseases

“…Upon the analysis of study results, all analyzed parameters of kidney dimensions correlated significantly with parameters of kidney function. 3,4,19,21,22 When this group was divided to subgroups by sex, the threshold of significance of tested correlation was not always achieved, most probably due to small number of subjects. 9,20 Burkhardt et al studied correlation between kidney dimensions and function in elderly and found the best correlation between the kidney parenchyma volume and creatinine clearance.…”

Determinants and Functional Significance of Renal Parenchymal Volume in Adults

“…The correlation between kidney size and renal function has not been carefully examined. Several studies have shown a good correlation between GFR and renal size measured urographically or sonographically in children (42)(43)(44)(45). Correlations between size and function have been found in adults with hypertension or renal disease using urography (46), in diabetics (1,38) and elderly hospitalized patients (47) using sonography, and in disease-free cancer patients using CT scanning (23).…”