Comparison between the Anti-Candida Activity of Fenugreek and Ginger rhizome Extracts and their Synergism with Fluconazole and Nystatin

Abstract

Background: Oropharyngeal candidiasis is an alarming sign that may indicates a serious systemic disorder, especially in immunocompromised individuals who face the drastic side effects of the in market antifungal drugs. This increases the need for developing effective and safe natural products. Objectives: to evaluate the in vitro activities of both Fenugreek and Ginger rhizome extracts and to compare their effects with nystatin and fluconazole antifungals against Candida species. As far as we know, this is the first study to compare between the anti-candida activity of both extracts. Methodology: Different species of Candida were isolated from patients suffering from oropharyngeal candidiasis. The antifungal effects of methanolic extracts of Fenugreek and Ginger rhizome were tested using disc diffusion method. Each extract was added to both nystatin and fluconazole discs to measure the presence of synergistic effects. Results: Highly significant synergism was detected between both extracts and fluconazole. Ginger rhizome extract was more potent than Fenugreek extract. Conclusion: When used in combination with fluconazole, Fenugreek and Ginger rhizome extracts are promising, safe and effective anti-Candida agents.