Comparison between the Effect of Melatonin and Zinc sulfate in Prevention of cisplatin induced Nephrotoxicity in Rats

Al-Zubaidy, Adeeb A.; Al-Salihy, Dalia Abd Al Kader; Alabbassi, Mustafa Ghazi

doi:10.32947/ajps.v12i2.260

Cited by 2 publications

References 23 publications

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The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

Esmaeli,

Ghanbari,

Roshankhah

et al. 2024

Preprint

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Background Administration of chemotherapeutic agents, such as cisplatin, induces infertility as a side effect in men of childbearing age, while consumption of antioxidants can recover this process. Therefore, the present study was designed to evaluate the protective effect of Sambucus nigra (SNA) on cisplatin alone and in combination in reducing the toxicity of cisplatin on the reproductive system of mice. Materials & methods In this study, 30 adult balb/c mice were randomly divided into 5 groups (n = 6). Mice in the groups received cisplatin (0.4 mg/kg) and SNA (200 mg/kg) intraperitoneally for three periods of six days with an interval of 10 days for a total of 48 days. The positive and negative control groups received normal saline and no drug, respectively. At the end of the treatment period, various parameters such as semen analysis, changes in testicular histological structures, changes in hormone levels, expression of apoptotic genes and the amount of malondialdehyde (MDA), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were evaluated. Results The results of the present study showed that SNA could significantly reduce abnormalities of sperm and testis due to cisplatin administration. In addition, SNA was able to reduce the expression of genes involved in the apoptotic pathway compared to the cisplatin group. Meanwhile, SNA reduced serum MDA rate and raised rate T-SOD, GSH-Px and CAT rate compared to the cisplatin group. Conclusion The findings of this study suggest that SNA may have a protective effect against cisplatin in testicular tissue via its antioxidant properties.

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The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

Esmaeli,

Ghanbari,

Roshankhah

et al. 2024

Preprint

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The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats

Mnati

Mshimesh

Mohammed

2022

AJPS

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Infertility is a worldwide problem affecting both genders, it can be defined as the inability of the adult males to make a fertile woman pregnant after one year of regular intercourse. Cisplatin considers one of the most potent antineoplastic drugs that is extensively used, alone or in combination with other antitumor agents, to manage solid and germ cell cancer. The major drawback in cisplatin treatment is its damaging consequence on various body tissue, including the testis, liver, renal and others. One of its pronounced adverse effects is testicular injury, which may proceed to end with infertility. Thiamine pyrophosphate is the active form of thiamine which has an important role in the oxidative phosphorylation pathway. It acts as a co-factor and energy source for many cellular enzymes, also it utilizes by pentose-phosphate shut that elevates NADPH and improves antioxidants level. This study aimed to evaluate the effect of thiamine pyrophosphate on sperm parameters and gonadotropic hormones (luteal and follicle-stimulating hormone) of male rats exposed to a single dose of cisplatin. Twenty-eight albino male rats were randomly grouped into four groups. Control group: received normal saline, Cisplatin group: received normal saline and cisplatin, TPP50 group: received thiamine pyrophosphate (50mg/kg) with cisplatin, and TPP100 group: as third group (TPP50) but thiamine pyrophosphate dose was 100 mg/kg. Semen samples used to measure the sperms viability and morphology, while serum samples were gathered to measure the levels of gonadotropic hormones (FSH and LH). This study revealed that rat’s testicular function was notably deteriorated by cisplatin administration, represented by a reduction in sperm parameters (viability and normal morphology), and serum gonadotropic hormones (FSH and LH). In this work, thiamine pyrophosphate was act as a protective agent that ameliorates rat’s testicular damage induced by cisplatin in a dose-dependent manner. The suggested mechanism may attribute to its antioxidant and anti-apoptotic action

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Comparison between the Effect of Melatonin and Zinc sulfate in Prevention of cisplatin induced Nephrotoxicity in Rats

Cited by 2 publications

References 23 publications

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

The effect of Sambucus nigra fruit extract in three chemotropic cycles of cisplatin drug on male reproductive system of mice

The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats

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