2018
DOI: 10.1155/2018/8901215
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Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes‐Induced Murine Sinusitis Model

Abstract: Streptococcus pyogenes (S. pyogenes) is a species of Gram-positive coccoid bacteria having many virulence factors. Its capsule and exotoxins can cause upper respiratory tract infections such as sinusitis. The general treatment for S. pyogenes-induced sinusitis is administration of antibiotics such as penicillin and macrolides; however, a serious problem associated with these antibiotics is their attenuated effect. Shin'iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine and tradition… Show more

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Cited by 3 publications
(4 citation statements)
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“… 21 NF-κB is well known as a crucial transcription mediator regulating the induction of the inflammatory response. 22 Xin-Yi-Qing-Fei-Tang also showed an effect against a variety of bacteria, 23 , 24 thus minimizing the risk of bacterial colonization after ulceration develops.…”
Section: Discussionmentioning
confidence: 99%
“… 21 NF-κB is well known as a crucial transcription mediator regulating the induction of the inflammatory response. 22 Xin-Yi-Qing-Fei-Tang also showed an effect against a variety of bacteria, 23 , 24 thus minimizing the risk of bacterial colonization after ulceration develops.…”
Section: Discussionmentioning
confidence: 99%
“…Evaluation of anti-inflammatory action in spleen and mesenteric lymph nodes was performed as described elsewhere [18]. Briefly, splenocytes and mesenteric lymph nodal cells prepared from ICR mice (3-week-old, female) were treated with 2% fatal bovine serum (FBS, Sigma-Aldrich, St. Louis, MO, USA), 100 U/mL penicillin (Wako Pure Chemical, Osaka, Japan), 100 μ g/mL streptomycin (Wako), and 10 μ g/mL of lipopolysaccharide (LPS) from E. coli serotype 026: B6, (Sigma-Aldrich) and LCEEs for 24 hours at 37°C, cultured at 5% CO 2 , and the concentrations of tumor necrosis factor- (TNF-) α and interferon- (INF-) γ in the subsequent culture medium were measured with ELISA kits (BioLegend, San Diego, CA, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Determination of proliferative response of spleen and mesenteric lymph nodal cells was described elsewhere [18]. After the mice were sacrificed by CO 2 inhalation, spleen and mesenteric lymph nodes were removed aseptically and those tissues were filtered and cultured in RPMI1640 medium (Wako) with 5% FBS.…”
Section: Methodsmentioning
confidence: 99%
“…The procedure of nasal cultures was described elsewhere [ 16 ]. In brief, the mice were sacrificed by CO 2 inhalation.…”
Section: Methodsmentioning
confidence: 99%