Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management

Reshma, ArunimaPadmakumar; Varghese, SheejaSaji; Pampadykandathil, LizymolPhilipose

doi:10.4103/jisp.jisp_684_20

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Another systematic review done by Reshma AP et al 35 , also concluded that limited evidence was reported regarding the superiority of PRF over PRP and T-PRF over PRF for the treatment of osseous defects. There was no significant difference among the platelet concentrates.…”

Section: Figure 3: Shows the Image Of The T-prf Membrane Placed In Th...mentioning

confidence: 99%

Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review

GUMMALURI,

GURUMOORTHY,

KANCHARLA

et al. 2023

Cumhuriyet Dental Journal

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Periodontal disease treatment is always a challenging task. Various treatment modalities have been applied for treating this painless chronic condition. With advancement in the field of research in dentistry researchers shifted towards the autologous products hence came the usage of platelet concentrates in various branches of dentistry. Initially fibrin glue, platelet rich plasma (PRP) have been tried but because of their drawbacks platelet rich fibrin (PRF) came into play. Due to possible contamination of silica particles in silica tubes or silica coated plastic tubes and shorter resorption time, titanium attracted the researchers. This lead to introduction of titanium platelet rich fibrin (T-PRF) a second generation platelet concentrate. This had a thicker fibrin meshwork, better cellular entrapment, greater resorption rate and titanium tubes are inert, better haemocompatible and non-corrosive. It also eliminates the possible contamination of silica test tubes and silica coated plastic tubes. Present article is a review on T-PRF and its usage in the field of dentistry.

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Section: Figure 3: Shows the Image Of The T-prf Membrane Placed In Th...mentioning

confidence: 99%

Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review

GUMMALURI,

GURUMOORTHY,

KANCHARLA

et al. 2023

Cumhuriyet Dental Journal

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Autogenous platelet concentrates for treatment of intrabony defects—A systematic review with meta‐analysis

Miron,

Moraschini,

Estrin

et al. 2024

Periodontology 2000

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To provide an overview of the use of autogenous platelet concentrates (APCs) in periodontal regeneration and to conduct a systematic review (SR) of the treatment outcomes of periodontal intrabony defects by using platelet‐rich fibrin (PRF) compared with other commonly utilized modalities. The eligibility criteria comprised randomized controlled trials (RCTs) comparing the clinical outcomes of PRF with that of other modalities. Studies were classified into 21 categories and into five different groups as follows: Group I (1) open flap debridement (OFD) alone versus OFD/PRF, (2) OFD versus Titanium‐PRF (T‐PRF) Group II, (3) Comparative PRF protocols (PRF vs. T‐PRF), Group III (Comparative Studies to PRF): (4) OFD/PRP versus OFD/PRF, (5) OFD/bone graft(BG)/PRGF versus OFD/BG/PRF, (6) OFD/EMD versus OFD/PRF, (7) OFD/BG/EMD versus OFD/BG/PRF, (8) OFD/collagen membrane (CM) versus OFD/PRF, (9) OFD/BG/BM versus OFD/BG/PRF, (10) OFD/BG versus OFD/PRF, Group IV (Addition of PRF to treatment groups) (11) OFD/BG versus OFD/BG/PRF, (12) OFD/GTR versus OFD/GTR + PRF (13) OFD/EMD versus OFD/EMD/PRF (14) OFD/BG/BM versus OFD/BG/BM/PRF, Group V (Addition of Biomaterial/Biomolecule to PRF): OFD/PRF versus … (15) OFD/PRF/BG, (16) OFD/PRF/antibiotic, (17) OFD/PRF/Metformin, (18) OFD/PRF/Bisphosphonates, (19) OFD/PRF/Statins, (20) OFD/BG/PRF versus OFD/BG/PRF/Statins, and (21) OFD/PRF/low‐level laser therapy (LLLT). Weighted means and forest plots were calculated for probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone fill (RBF). From 596 records identified, 55 RCTs were included. Group I: The use of OFD/PRF statistically significantly reduced PPD and improved CAL and RBF when compared to OFD. Group II: A significant difference between various PRF protocols was only observed for PPD. Group III: No significant advantage was found when comparing OFD/PRF to the following groups: OFD/PRP, OFD/EMD, OFD/BM, or OFD/BG. Group IV: The addition of PRF to OFD/BG led to significant improvements in PPD, CAL and RBF compared with OFD/BG alone. Group V: The addition of either a BG as well as three of the following biomolecules (metformin, bisphosphonates, and statins) to OFD/PRF led to statistically significant improvements in PPD, CAL, and/or RBF when compared to OFD/PRF alone. The use of PRF significantly improved clinical outcomes in intrabony defects when compared to OFD alone. Similar results were observed when OFD/PRF was compared with OFD/BG, OFD/EMD, OFD/PRP, and OFD/BM. The addition of PRF to a bone grafting material as well as the addition of various small biomolecules to PRF may offer additional clinical advantages, thus warranting further investigations. Future research investigating various protocols of PRF, longer‐term outcomes, as well as PRF at the human histological level remains needed.

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Pretreatment with platelet-rich plasma protects against ischemia–reperfusion induced flap injury by deactivating the JAK/STAT pathway in mice

Su,

Xie,

et al. 2024

Mol Med

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Background Ischemia–reperfusion (I/R) injury is a major cause of surgical skin flap compromise and organ dysfunction. Platelet-rich plasma (PRP) is an autologous product rich in growth factors, with tissue regenerative potential. PRP has shown promise in multiple I/R-induced tissue injuries, but its effects on skin flap injury remain unexplored. Methods We evaluated the effects of PRP on I/R-injured skin flaps, optimal timing of PRP administration, and the involved mechanisms. Results PRP protected against I/R-induced skin flap injury by improving flap survival, promoting blood perfusion and angiogenesis, suppressing oxidative stress and inflammatory response, and reducing apoptosis, at least partly via deactivating Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signalling pathway. PRP given before ischemia displayed overall advantages over that given before reperfusion or during reperfusion. In addition, PRP pretreatment had a stronger ability to reverse I/R-induced JAK/STAT activation and apoptosis than AG490, a specific inhibitor of JAK/STAT signalling. Conclusions This study firstly demonstrates the protective role of PRP against I/R-injured skin flaps through negative regulation of JAK/STAT activation, with PRP pretreatment showing optimal therapeutic effects.

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Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management

Cited by 4 publications

References 26 publications

Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review

Evaluating the Predictability and Regenerative Capacity of Novel Platelet Concentrate (PC)-Titanium Platelet Rich Fibrin (T-PRF) in the field of Dentistry- A Narrative Review

Autogenous platelet concentrates for treatment of intrabony defects—A systematic review with meta‐analysis

Pretreatment with platelet-rich plasma protects against ischemia–reperfusion induced flap injury by deactivating the JAK/STAT pathway in mice

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