Comparison between total knee arthroplasty and MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis) for the treatment of osteoarthritis of the knee

Kim, Jang Mook; Han, Ju Rang; Shetty, Asode Ananthram; Kim, Seok Jung; Choi, Nam Yong; Park, Joon Su

doi:10.1007/s13770-014-0041-8

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Bone marrow-derived MSCs have been demonstrated to possess anti-inflammatory, immunomodulatory, anti-apoptotic, antibacterial and chondrogenic properties [5]. Due For reprint orders, please contact: reprints@futuremedicine.com future science group Case Series Sampson, Smith, Vincent, Aufiero, Zall & Botto-van-Bemden to the potential therapeutic benefits of bone marrowderived MSCs, multiple researchers have begun to explore the safety and efficacy of MSCs to treat a variety of joint disorders, including OA [5][6][7][8], osteochondral lesions [9][10][11][12][13][14], meniscus tears [15], nonunion fractures and spine-mediated pain [16,17]. In addition, autologous BMC has demonstrated promise when utilized intraoperatively as an adjunct to debridement or microfracture surgery for cartilage defects [13,[18][19][20][21][22].…”

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confidence: 99%

Intra-Articular Bone Marrow Concentrate Injection Protocol: Short-Term Efficacy in Osteoarthritis

et al. 2016

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confidence: 99%

Intra-Articular Bone Marrow Concentrate Injection Protocol: Short-Term Efficacy in Osteoarthritis

et al. 2016

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“…Kim et al introduced new arthroscopic technique to overcome this problems using CO 2 gas instead of normal saline during BMAC and gel matrix injection. 36 There are several advantages to using this method. An arthrotomy required in ACI is not necessary to implant the composite scaffold to the lesion.…”

Section: Novel Arthroscopic Technique Using Co 2 Gasmentioning

confidence: 99%

Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC)

Huh

Shetty

Ahmed

et al. 2016

Journal of Clinical Orthopaedics and Trauma

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Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population. There have been multiple approaches to treat such lesions, including arthroscopic debridement, microfracture, multiple drilling, osteochondral transplantation and autologous chondrocyte implantation (ACI) that are currently being used in clinical practice. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) is a single-staged arthroscopic procedure. This method combines a modified microfracture technique with the application of a bone marrow aspirate concentrate (BMAC), hyaluronic acid and fibrin gel to treat articular cartilage defects. We reviewed the current literatures and surgical techniques for mesenchymal cell induced chondrogenesis.

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“…Chondrocytes are the cells responsible for the production of cartilage extracellular matrix (ECM) including type II collagen and proteoglycans. Therefore, chondrocytes represent the logical choice for cell-based therapies in cartilage tissue regeneration [8][9][10][11][12]. The most conventional cell-based treatment is autologous chondrocyte implantation (ACI) [8,13].…”

Section: Introductionmentioning

confidence: 99%

Chondrogenic Potential of Dedifferentiated Rat Chondrocytes Reevaluated in Two- and Three-Dimensional Culture Conditions

Jin

Kim

2017

Tissue Eng Regen Med

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For the cartilage repair, the cell sources currently adopted are primarily chondrocytes or mesenchymal stem cells (MSCs). Due to the fact that chondrocytes dedifferentiate during 2-dimensional (2D) expansion, MSCs are generally more studied and considered to have higher potential for cartilage repair purposes. Here we question if the dedifferentiated chondrocytes can regain the chondrogenic potential, to find potential applications in cartilage repair. For this we chose chondrocytes at passage 12 (considered to have sufficiently dedifferentiated) and the expression of chondrogenic phenotypes and matrix syntheses were examined over 14 days. In particular, the chondrogenic potential of MSCs was also compared. Results showed that the dedifferentiated chondrocytes proliferated actively over 14 days with almost 2.5-fold increase relative to MSCs. Moreover, the chondrogenic ability of chondrocytes was significantly higher than that of MSCs, as confirmed by the expression of a series of mRNA levels and the production of cartilage extracellular matrix molecules in 2D-monolayer and 3-dimensional (3D)-spheroid cultures. Of note, the significance was higher in 3D-culture than in 2Dculture. Although more studies are needed such as the use of different cell passages and human cell source, and the chondrogenic confirmation under in vivo conditions, this study showing that the dedifferentiated chondrocytes can also be a suitable cell source for the cell-based cartilage repair, as a counterpart of MSCs, will encourage further studies regarding this issue.

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Comparison between total knee arthroplasty and MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis) for the treatment of osteoarthritis of the knee

Cited by 4 publications

References 26 publications

Intra-Articular Bone Marrow Concentrate Injection Protocol: Short-Term Efficacy in Osteoarthritis

Intra-Articular Bone Marrow Concentrate Injection Protocol: Short-Term Efficacy in Osteoarthritis

Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC)

Chondrogenic Potential of Dedifferentiated Rat Chondrocytes Reevaluated in Two- and Three-Dimensional Culture Conditions

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