Comparison of 60 and 80 mg/m² of daunorubicin in induction therapy of acute myeloid leukaemia

Abstract

For finding better method of acute myeloid leukaemia (AML) induction, we designed a prospective clinical trial to find a more effective regimen with least toxicity for induction therapy of AML. Hence, we examined different accepted doses of daunorubicin and their outcomes. Total of 114 patients were included in the study. Fifty-five patients received 60 mg/m 2 of daunorubicin (arm 1) 1 h IV infusion for 3 days, and the remaining 59 received 80 mg/m 2 (arm 2) 1 h IV infusion for 3 days. Continuous infusion of 100 mg/m 2 /day of cytosine arabinozide IV for 24 h for 7 days was given in both groups. Complete remission rate was 77.78% in group 1 and 76.92% in group 2 (p = 0.92). One-year overall survival was 55.85% [standard error (SE) = 8.05%] in arm 1 and 57.94% (SE = 7.32%) in arm 2. Median follow-up time was 11.1 (SE = 1.43) and 10.28 (SE = 1.29) months, respectively. One-year disease-free survival was 64.41% (SE = 7.39%) in arm 1 and 54.86% (SE = 7.53%) in arm 2. Complete remission, overall survival and disease-free survival were statistically the same in both groups (p = 0.92, 0.697, 0.31). Toxicity and safety profile were similar in two groups but need to transfusion was higher in arm 2. Febrile neutropenia, days of antibiotics consumption and invasive fungal infection prevalence did not show any difference. Mean transfused packed cells and platelets rate were higher in the group that received higher dose of daunorubicin. Considering these results, we found that 60 mg/m 2 of daunorubicin would be more rational and as effective with lower toxicity to 80 mg/m 2 in induction therapy of AML patients at least as scheduled in our trial.

Bio-adsorbents for the Removal of Heavy Metals from Water

“…Long-term exposure to arsenic, through water and food, can lead to serious health problems like neurological effects, hypertension and cardiovascular diseases, and skin and lung cancer [7]. The kidney is the major source for regulation of water and electrolytes, waste, and chemical compounds, and arsenic(III) can affect the role of the proximal tubules and glomerulus of the kidney [8].…”

Outcome analysis of acute myeloid leukemia patients treated with high dose daunorubicin

“…The incidence of AML is more common in men, and the ratio of incidence in men to women is 3 to 2. The incidence of AML increases with aging [9][10][11][12] . Several etiologies are associated with AML incidence, including dysplastic diseases, congenital diseases (Down syndrome, Fanconi anemia), and environmental exposures (ionizing radiation, chemical exposures, and history of chemotherapy) [13][14][15] .…”