Comparison of 99mTc Phosphate and Diphosphonate Complexes in Experimental Renal Infarcts

An optimized imaging protocol for [99mTc]Tc-DPD scintigraphy and SPECT/CT quantification in cardiac transthyretin (ATTR) amyloidosis

“…Scully et al demonstrated almost perfect differentiation of DPD positive and negative cases based on the cardiac peak standardized uptake value (SUVpeak) in 100 patients (AUC 0.999). 18 To ensure representativeness for clinical conditions, filling of the cardiac phantom was based on the [ 99m Tc] Tc-DPD blood pool activity concentration that can be expected in patient examinations 17,[33][34][35] and based on SBR derived from own patient samples of positive DPD scans. However, underestimation of myocardial activity in patients could still result from cardiac movement due to breathing and ventricular contractions, although gated data acquisition would-ideally-compensate for the latter.…”

Increased Patchy Renal Accumulation of ^99mTc-Methylene Diphosphonate in a Patient with Severe Loin Pain after Exercise

“…The predominant intense patchy accu mulation of the radioisotope in the right kidney was in accordance with the predominant wedge-shaped con trast enhancement in the right kidney observed by com puted tomography. Renal ischemia during septic shock [5], experimental artery occlusion [6], renovascular steno sis [7] and renal transplantation [8] revealed diffuse renal parenchymal accumulation of " mTc-MDP. 99mTc-MDP in ischemic kidney accumulates more intensely than 99mTc-DMSA or DTPA [9].…”

Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent

“…Indeed, this chemical modification was necessary for the stabilization of the iron core in physiological conditions [34,35]. Another advantage of this grafting was that 99m Tc can be linked to the peptide by chelation via the bisphosphonate group [47] and therefore offers a fast and efficient opportunity to test the modified peptide binding capabilities in vivo using γ -counting. Thus, the injection of 99m Tc BP-IELLQAR into rats that have experienced traumatic brain injury induced a significant accumulation of the peptide in the traumatized hemisphere ( Fig.…”