Comparison of a Novel Method vs the Friedewald Equation for Estimating Low-Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile

Comparison of equations for the calculation of LDL-cholesterol in hospitalized patients

“…However, a subsequent validation study found uncertainties in both this novel formula and Friedewald at low LDL-C levels (<1.18 mmol/l) [22]. Accuracy of the formulae may be improved where TG/VLDL-C ratios are taken into consideration [21], particularly in hypertriglyceridaemic patients. The authors found that most of the variance in the ratios could be explained by TG and non-HDL-C levels.…”

“…In a prospective study of 2222 men free from ischaemic heart disease (IHD), correction of the Friedewald formula to account for Lp(a) levels (the Dahlen modification) did not improve the evaluation of IHD risk [37]. One recent study considered the variance in the TG:Very low density lipoprotein cholesterol (VLDL-C) ratio, and found that using a 180 panel specific to TG and HDL-C levels improves the accuracy of their formula (non-HDL-C -TG/adjustable factor mg/dL) as compared to Friedewald [21]. However, a subsequent validation study found uncertainties in both this novel formula and Friedewald at low LDL-C levels (<1.18 mmol/l) [22].…”

“…renal failure or diabetes) [2,11], but is widely used. Several other formulae have been developed, but these did not perform better than Friedewald's calculation [12][13][14] or had varying results in different population groups [10,[15][16][17][18][19] and including those considering TG ratios [20,21]. In the latest study validating a novel formula in comparison with Friedewald's calculation and the LDL-C reference method in 23 055 patients, the benefits over…”

Reporting LDL-cholesterol levels in the era of intensive lipid management: a clarion call

“…Underestimation of the LDL-C by the Friedewald equation is most manifest at low LDL-C levels and high TG levels [3]. In their study examining over a million patients with LDL-C estimation performed by Friedewald and ultracentrifugation, Martin et al found that the Friedewald equation underestimates LDL-C leading to incorrect classification of risk groups [4]. They found this to occur particularly in the presence of TGs levels >2.3 mmol/L (200 mg/dL) and LDL-C < 1.8 mmol/L where the concordance was only 40.3%.…”

Evaluation of Recently Developed Regression Equation with Direct Measurement of Low-density Lipoprotein Cholesterol in a Bangladeshi Population

“…But there are several shortcomings while using this formula -underestimation of LDL cholesterol at higher TG levels [7][8][9][10][11][12][13] and overestimation at low TG levels. 14 Recently by analyzing lipid profiles from 1.3 million consecutive adult subjects referred for direct measurement of cholesterol subfraction by the Vertical Auto Profile (VAP, density gradient ultracentrifugation or vertical spin density gradient ultracentrifugation) Martin et al [15][16][17] also reported a meaningful underestimation of LDL cholesterol in US adults. These are related to the use of fixed value of TG to VLDL cholesterol.…”