Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs

Suarez, Martin A.; Dzikiti, Brighton T.; Stegmann, Frik G; Hartman, Marthinus Jacobus

doi:10.1111/j.1467-2995.2011.00700.x

Cited by 94 publications

(137 citation statements)

References 30 publications

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“…However, it was determined that MAP value detected during premedication in PRO group was higher than those detected during other measured times but MAP value decreased all measured times in ISO group. Unlike Suarez et al [4] reported a decrement in HR, it was observed that HR value did not show any significant difference between groups. The researchers also indicated that the infusion of propofol and alphaxolane had adequate anesthesia for ovariohysterectomy in dogs premedicated with acepromazine and morphine however, ventilatory support was needed due to long-term hypoventilation caused by using of these anesthetic agents [4] .…”

Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Socontrasting

confidence: 72%

“…Unlike Suarez et al [4] reported a decrement in HR, it was observed that HR value did not show any significant difference between groups. The researchers also indicated that the infusion of propofol and alphaxolane had adequate anesthesia for ovariohysterectomy in dogs premedicated with acepromazine and morphine however, ventilatory support was needed due to long-term hypoventilation caused by using of these anesthetic agents [4] . In the present study, all ovariohysterectomie procedure was ended in 30 min and SpO 2 value in PRO group which TIVA was used, was in normal range throughout the surgery.…”

Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Socontrasting

confidence: 72%

“…Propofol which is characterized by tranquilising and fast anesthesia induction has been reported to have short duration of recovery when it is used as constant rate infusion (CRI) for maintenance of anesthesia and decreases HR and MAP under therapeutic dose range [4] . In current study, SAP and DAP values in PRO and ISO groups were compared, no significant difference was observed.…”

Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Somentioning

confidence: 99%

“…TIVA is a general anesthesia technique which is used to induction of anesthesia by intravenously given drugs and maintains the anesthesia [4] . Propofol (2,6-diisopropylphenol) is an intravenously using anesthetic agent in alkyl phenol family [4,5] .…”

Section: Introductionmentioning

confidence: 99%

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Determination of Propofol and Isoflurane Anesthesia Depth with Bispectral Index Monitorization in Dogs Undergoing Ovariohysterectomy Procedure

Saritaş¹,

Yilmaz²,

Korkmaz³

et al. 2014

Kafkas Univ Vet Fak Derg

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SummaryIn this study, 12 bitches were used to compare anesthetic depth by bispectral index (BIS) monitoring and vital parameters under propofol and isoflurane anesthesia. The animals were randomly divided into two groups (n=6) for ovariohysterectomy. All animals were premedicated with atropine sulphate (0.04 mg/kg, sc) and midazolam (0.3 mg/kg, iv). The induction of anesthesia was achieved by propofol (5 mg/kg, iv) in groups. General anesthesia was maintained with propofol (0.4 mg/kg/min.) in first group (PRO group) and 2% isoflurane in second group (ISO group). Non-invasive systolic (SAP), diastolic (DAP), mean arterial blood pressure (MAP), heart rate (HR), respiratory rate (RR), haemoglobin oxygen saturation (SpO 2 ) and BIS were measured before anesthesia (0 min, T0), maintenance of anesthesia (T5, T10, T15), end of anesthesia (T30) and additionally BIS also measured at 5 min after the terminating of anesthesia (T35). HR, RR, SAP and DAP did not significantly differ between groups. The MAP value did not show any significant difference within both groups. However, the MAP value detected on T5, T10, T15 and T30 was higher in PRO group than those detected in ISO group (P<0.05). The BIS values detected at all measured times in PRO and ISO groups were lower than those detected before anesthesia. The BIS value detected on T5 and T10 was higher in ISO group, whereas the value determined at T15 was higher in PRO group (P<0.05). In conclusion, it is suggested that bispectral index is a useful tool for monitoring depth of anesthesia in veterinary practice and total intravenous anesthesia with propofol may be used as an alternative to isoflurane anesthesia. Keywords: Bispectral Index, Dog, Isoflurane, Propofol Ovariohisterektomi Yapılan Köpeklerde Propofol ve İzofloran Anestezisinin Derinliğinin Bispektral İndeks Monitörizasyonu ile Belirlenmesi ÖzetBu çalışmada, propofol ve izofluran anestezisinde anestezi derinliğinin bispektral indeks (BIS) ve vital parametrelerin izlenmesi ile karşılaştırılması için 12 adet dişi köpek kullanıldı. Hayvanlar ovariohisterektomi operasyonu için rastgele iki gruba bölündü (n=6 her grupta). Hayvanlar atropin sülfat (0.04 mg/kg, sc) ve midazolam (0.3 mg/kg, iv) ile premedike edildi. Anestezi indüksiyonu gruplarda propofol (5 mg/kg, iv) ile sağlandı. Genel anestezi ilk grupta propofol (PRO grubu) ile ikinci grupta %2 izofluran (ISO grubu) ile devam ettirildi. Non-invaziv sistolik (SAP), diastolik (DAP), ortalama arteriyel kan basıncı (MAP), nabız sayısı (HR), solunum sayısı (RR), hemoglobin oksijen saturasyonu (SpO 2 ) ve BIS anestezi öncesi (0. dakika, T0), anestezi boyunca (T5, T10, T15) ve anestezi sonunda (T30) ölçülürken BIS ölçümü anestezi sonlandırıldıktan 5 dakika sonra (T35) da ölçüldü. HR, RR, SAP ve DAP değerleri gruplar arasında farklılık göstermedi. MAP değeri her iki grup içinde istatiktiksel olarak farklılık oluşturmadı. Bununla birlikte, T5, T10, T15 ve T30 ölçüm zamanlarında PRO grubundaki MAP değerinin ISO grubuna göre yüksek olduğu belirlendi (P<0.05). PRO ve ISO gruplar...

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Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Socontrasting

confidence: 72%

Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Socontrasting

confidence: 72%

Section: Tablo 1 Propofol Ve Izofluran Gruplarında Kalp Frekansı Somentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of Propofol and Isoflurane Anesthesia Depth with Bispectral Index Monitorization in Dogs Undergoing Ovariohysterectomy Procedure

Saritaş¹,

Yilmaz²,

Korkmaz³

et al. 2014

Kafkas Univ Vet Fak Derg

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“…Segundo um estudo realizado em macacos da espécie Macaca mulatta, demonstrou que o tempo de recuperação anestésica após contenção química utilizando propofol (6mg/kg/IV) foi de 22,5 ± 3,2 minutos, ligeiramente inferior quando comparado à associação cetamina (8mg/kg/IM) midazolam (0,2 mg/kg/IM), que durou 41,2 ± 5,9 minutos. O propofol tem sido amplamente utilizado em protocolos de anestesia intravenosa, sendo seu uso muito difundido na Medicina Veterinária e humana (SUAREZ et al, 2012, YOO et al, 2012.…”

Section: Introductionunclassified

Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

et al. 2013

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ResumoEstudos sobre eletrocardiograma (ECG) em Sapajus apella são restritos na literatura científica. Primatas não humanos podem ser sedados com benzodiazepínicos e após induzidos e mantidos anestesiados com propofol. O objetivo do presente estudo foi à descrição dos achados eletrocardiográficos em 18 macacos-prego (Sapajus apella) após sedação com midazolam e anestesia com propofol. A interpretação do eletrocardiograma foi realizada determinando-se os seguintes parâmetros: frequência (FC) e ritmo cardíaco, eixo elétrico (°), onda P, onda R, onda T, complexo QRS, intervalo P-R, intervalo Q-T e segmento ST. A FC média foi de 198,4 ± 22,9 bpm, a maioria dos macacos tinham ritmo sinusal normal, seguido de ritmo sinusal normal com marcapasso migratório. O eixo elétrico mais comumente observado manteve-se entre 60-90°. A administração intramuscular de midazolam, seguida de anestesia geral de curta ação com propofol não causou arritmias no traçado eletrocardiográfico e preservou a FC nos limites considerados fisiológicos para a espécie. Consequentemente, houve uma duração maior do intervalo Q-T comparado com estudos anteriores que utilizaram somente cetamina. Palavras-chave: Sapajus apella, propofol, midazolam, eletrocardiograma AbstractStudies on electrocardiography in Sapajus apella are restricted in the scientific literature. Nonhuman primates can be sedated with benzodiazepine and after induced and maintained anesthetized with propofol. The objective of the present study was to description of the electrocardiographic findings in 18 capuchin monkeys (Sapajus apella) after sedation with midazolam and anesthesia with propofol. The interpretation of the ECG was performed by determining the following parameters: frequency (HR) and heart rhythm, electrical axis (°) P wave, R wave, T wave, QRS complex, P-R interval, Q-T interval and ST segment. The HR mean was 198,4 ± 22,9 bpm, the majority of monkeys had normal sinus rhythm, followed by normal sinus rhythm with wandering pacemaker. The most commonly observed electrical axis was between 60-90°. Intramuscular administration of midazolam, followed by a shortacting general anesthesia with propofol did not cause arrhythmias in electrocardiographic tracing and preserved the FC in the limits considered physiological for to specie. Consequently, there was a longer

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Injectable Anesthetics

Berry

2015

Veterinary Anesthesia and Analgesia

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Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs

Cited by 94 publications

References 30 publications

Determination of Propofol and Isoflurane Anesthesia Depth with Bispectral Index Monitorization in Dogs Undergoing Ovariohysterectomy Procedure

Determination of Propofol and Isoflurane Anesthesia Depth with Bispectral Index Monitorization in Dogs Undergoing Ovariohysterectomy Procedure

Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

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