Comparison of apparent diffusion coefficient in spondylarthritis axial active inflammatory lesions and type 1 modic changes

Dallaudière, B.; Dautry, Raphaël; Preux, Pierre‐Marie; Perozziello, Anne; Lincot, J.; Schouman-Claeys, É.; Serfaty, Jean Michel

doi:10.1016/j.ejrad.2013.10.009

Cited by 26 publications

(22 citation statements)

References 19 publications

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“…On the contrary, DWI has been well established as an effective method in evaluating the degree of active inflammation in many disease states and has the additional advantage of being able to quantify diffusion coefficients with ADC measurements [2,22]. We agree with several authors that using DWI with ADC values may complement STIR images and even outperform STIR images in patients with SpA [2,3,[23][24][25][26][27][28]. Therefore, in addition to the SPARCC MRI Index, we also performed DWI(ADC) for the SI joints and axial spine to quantify and compare the degree of inflammation in our cohort.…”

Section: Discussionsupporting

confidence: 72%

“…Other conditions such as tumours, infection, trauma etc., are relatively uncommon. Although Dallaudière et al [25] reported that ADC values may be able to discriminate between axial inflammatory lesions and type 1 Modic lesions, we performed additional subgroup analysis to exclude all films with Modic lesions to further confirm our findings.…”

Section: Discussionsupporting

confidence: 57%

“…First, no objective gold standard currently exists for the use of DWI and ADC values in the diagnosis and assessment of SpA. However, many other reports have also found DWI and ADC values to correlate well with disease activity in SpA [2,3,[23][24][25][26][27], although reports on the use of DWI on assessing axial involvement are scarce. Further studies and international collaborations would be required to standardize the use of different MRI modalities (such as DWI and ADC values) in the management of SpA.…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis

Chung

Wong

et al. 2019

Journal of Clinical Rheumatology and Immunology

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Objective: To investigate the associations between age and clinical and radiological disease activities in axial SpA. Methods: One hundred and twenty-one patients fulfilling the Assessment of SpondyloArthritis International Society Classification Criteria for axial SpA were included in analyses. Patient demographics, disease activity and radiographic scores, as well as magnetic resonance imaging (MRI) with diffusion weighted imaging derived apparent diffusion coefficient values (DWI(ADC)), were compared between patients aged > 40 and [Formula: see text] 40 years at a cross-sectional level. Variables with significant differences in univariate analyses were used as dependent variables in multivariate linear regression models adjusted for potential confounding/contributing factors. Results: Multivariate analysis showed that increasing age was significantly associated with higher Bath Ankylosing Spondylitis Functional Index (B = 0.04, p < 0.01) and Bath Ankylosing Spondylitis Metrology Index scores (B = 0.04, p < 0.01); as well as higher modified Stoke Ankylosing Spondylitis Spine Score (B = 0.41, p < 0.01). On MRI, increasing age was associated with a lower DWI(ADC) (B = (-0.01), p < 0.01) of the SI joints, but higher DWI(ADC) values of the axial spine (B = 0.01, p = 0.01). Conclusion: Increasing age in SpA was associated with greater functional impairment and structural damage, more inflammation of the axial spine, but less inflammation of the SI joints. Our findings are consistent with the traditional belief that SpA is an “ascending disease” and highlights the importance of different modalities of MRI in the diagnosis and disease monitoring of SpA.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis

Chung

Wong

et al. 2019

Journal of Clinical Rheumatology and Immunology

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“…Diffusion-weighted imaging (DWI) has been proven to be an effective tool for diagnosing the activity of AS [12], especially in monitoring AS therapy [9]. However, the monoexponential decay of signals shown by the apparent diffusion coefficient (ADC) of DW-MRI is able not only to explore the diffusion of water protons in tissue, but can also be affected by the structures of the tissue and perfusion in the capillary network.…”

Section: Snrmentioning

confidence: 99%

Detection of Active Sacroiliitis with Ankylosing Spondylitis through Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging

Zhao

Liu

et al. 2015

Eur Radiol

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Objective To confirm feasibility and assess intravoxel incoherent motion (IVIM) to differentiate active sacroiliitis and ankylosing spondylitis.. Methods Forty-one patients were divided into two groups, an active group (n=20) and a chronic group (n=21), according to the Bath Ankylosing Spondylitis (AS) Disease Activity Index (BASDAI) and laboratory parameters. In addition, 21 healthy volunteers were chosen as the control group. Tissue diffusivity (D slow ), perfusion fraction (f), and pseudo-diffusion coefficient (D fast ) values were obtained for all three groups. Oneway analysis of variance and receiver operating characteristic analysis were performed for all parameters. Results There was good interobserver agreement on the measurements between the two observers. The optimal cutoff values (with respective AUC, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio) between active and chronic groups were D slow =0.53×10 −3 mm 2 /s (0.976, 90 %, 95.2 %, 18.9, 0.10) and f= 0. 09 (0.545, 20 %, 95.5 %, 4.2, 0.84), and between chronic and control groups were D slow = 0.22 × 10 −3 mm 2 /s (0.517, 9.52 %, 100 %, no number, 0.9) and f = 0.09 (0.935, 95.24 %, 80.95 %, 5, 0.059).Conclusion D slow and f of IVIM diffusion-weighted (DW)-MRI in AS show a significant difference in the values of diffusion of water molecules and fractional perfusion-related volume among the three groups. Key Points• D slow can be used to differentiate the activity of AS.• With perfusion fraction, the sensitivity of differentiating the AS activity is improved. • IVIM DWI plays an important role in detecting the activity in patients with AS.

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“…[33][34][35][36][37]39 In a study focusing on axial inflammatory lesions in SpA patients, ADC values were significantly higher in axial inflammatory lesions of patients with SpA as compared with a group of patients with degenerative type 1 Modic changes in the axial skeleton. 40 Thus far, one study looked at treatment response of SpA patients and possible change in ADC values. Decreasing ADC in lesions adjacent to the SI joints or in the thoracolumbar spine was found in patients who showed clinical response to infliximab treatment.…”

Section: Dwi In Spondylarthropathymentioning

confidence: 99%

Novel Imaging Techniques in Rheumatic Diseases

Hemke

Mascarenhas

Maas

2018

Semin Musculoskelet Radiol

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Since the introduction of new MR imaging techniques within the past two decades, the imaging assessment of joints in rheumatic diseases has changed considerably. MRI enables to evaluate both the inflamed synovial membrane as well as early structural damage. In the last few years, several new functional/metabolic MR imaging techniques have applied in rheumatic diseases, making it possible to evaluate the pathophysiology of the disease in greater detail. Moreover, they permit a more quantitative approach for the evaluation of disease activity and damage. Several functional imaging techniques in rheumatic diseases have been proposed for the evaluation and monitoring of disease status.

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Comparison of apparent diffusion coefficient in spondylarthritis axial active inflammatory lesions and type 1 modic changes

Cited by 26 publications

References 19 publications

The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis

The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis

Detection of Active Sacroiliitis with Ankylosing Spondylitis through Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging

Novel Imaging Techniques in Rheumatic Diseases

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