Comparison of atopic features between children and adults with eosinophilic esophagitis

Abstract

ABSTRACT

Seasonal distribution of initial diagnosis and clinical recrudescence of eosinophilic esophagitis: a systematic review and meta‐analysis

“…Thus, it is not unusual for EoE patients to suffer atopic exacerbations during the pollen season and to seek out allergist care because of it, thereby providing an increased likelihood of receiving a diagnosis of EoE during the same season. Atopic features and allergy sensitization patterns in EoE patients are similar to those of atopic non‐EoE individuals living in the same geographical area and exposed to common allergens , with no significant differences regarding family background of atopy, and personal history of allergic rhinitis, atopic dermatitis, immunoglobulin E‐mediated food allergy, or sensitization to aeroallergens between the two groups, either in children or in adults .…”

Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis

“…In addition to atopic disorders such as atopic dermatitis and asthma (19,20), EoE has been observed in the presence of other comorbidities, including a spectrum of inherited connective tissue disorders (CTD) characterized by hypermobility syndrome, suggesting common disease pathways (21). For instance, TGF-β-mediated fibrotic responses have been implicated in both esophageal remodeling and dysmotility in EoE and the CTDs Marfan syndrome and Loeys-Dietz syndrome (21)(22)(23)(24)(25).…”

Prevalence of atopic disease in patients with eosinophilic esophagitis

“…Specifically, it has been hypothesized that eosinophils migrate to the esophagus in response to various ingested and/or inhaled allergens, thus associating EoE to allergy‐induced diseases . As a result, high prevalence of atopic diseases (eg, asthma, allergic rhinitis [AR] and atopic dermatitis [AD]) and sensitization to food and environment allergens is seen in pediatric and adult EoE populations . However, most studies describe concomitant disease as self‐reported by the patients and thus are prone to bias and underrepresentation or overrepresentation of comorbidities…”