Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine

Ciano, Patricia Di; Coury, Ariane; Depoortère, R.; Egilmez, Y.; Lane, John D.; Emmett‐Oglesby, M. W.; LePiane, Fredric G.; Phillips, Anthony G.; Blaha, C. D.

doi:10.1097/00008877-199506000-00002

Cited by 62 publications

(50 citation statements)

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“…2,4,17 During the first 24 h of unlimited access period (Training Sessions, day 4), there were no significant differences in the total d-AMPH intake between Binge, Abstinent, and Relapse groups, with all three groups averaging approximately 12.5 mg/kg (data not shown). During both the first and second unlimited access session (Testing Session, day 6), all animals directed their respondses almost entirely towards the active lever.…”

Section: D-amph Ivsamentioning

confidence: 94%

“…The 3-h minimum used in the d-AMPH Binge, Abstinent, and Relapse groups was chosen based on previous studies from our laboratory that measured the efflux of DA and DA metabolites resulting from d-AMPH IVSA under continuous access conditions. 2,4,8,17 For the Binge and Relapse groups, 3 h of IVSA has been demonstrated to significantly elevate DA efflux compared to baseline levels, and decrease DA metabolites DOPAC and HVA compared to baseline levels. For the Abstinent group, previous behavioral data indicate that the majority of rats that voluntarily ceased to respond to d-AMPH for 3 consecutive hours remained in the abstinent state for an average of 18 h. 2,4,8,17 2-DIGE and data analysis…”

Section: Amphetamine Self-administrationmentioning

confidence: 96%

“…Following food training, rats were surgically implanted with a chronically indwelling jugular cannula, as previously described. 17 Briefly, rats were anaesthetized with ketamine (100 mg/kg, i.p.) and xylazine (8 mg/kg, i.p.)…”

Section: Surgery and Trainingmentioning

confidence: 99%

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Distinct proteomic profiles of amphetamine self-administration transitional states

et al. 2005

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In the rat, continuous access to d-amphetamine (d-AMPH) leads to lengthy bouts of self-administration, voluntary abstinence, and relapse to selfadministration. Previous studies have revealed that the progression from psychostimulant self-administration to abstinence to relapse is mediated in part by the ventral hippocampus. Stimulation of the ventral subiculum (vSub) during voluntary abstinence from d-AMPH self-administration reinstates self-administration and increases nucleus accumbens (NAc) dopamine efflux. Quantitative proteomic examination of the hippocampus from rats naïve to amphetamine, during a self-administration session 'Binge', during voluntarily abstinence 'Abstinent', and after reinstatement of selfadministration 'Relapse', revealed a differential proteomic state during abstinence. Actin-and cytoskeletal-related proteins were over-represented in the changes occurring during abstinence and suggest a decrease in actin filament polymerization. These changes may underlie alterations in neuronal tone during abstinence that could affect both neurotransmission and behavior. These data provide the first classification of addiction-related behaviors based on clustering of quantitative proteomic measurements.

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Section: D-amph Ivsamentioning

confidence: 94%

Section: Amphetamine Self-administrationmentioning

confidence: 96%

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Distinct proteomic profiles of amphetamine self-administration transitional states

et al. 2005

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“…Microdialysis studies, in addition, have shown that cocaine increases extracellular DA in the NAc even after i.v. self-administration (Di Ciano et al, 1995;Justice, 1989, 1991;Wise et al, 1995;Lecca et al, 2007a). Moreover, preferential stimulation of DA transmission in the ventral striatum by amphetamine has been demonstrated in humans by Positron Emission Tomography of [ 11 C] raclopride binding (Drevets et al,1999(Drevets et al, , 2001Leyton et al, 2002;Martinez et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

et al. 2015

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Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor (D1aR) expression was impaired in the NAc shell and core by locally infusing lentiviral vectors (LV) expressing specific D1aR-siRNAs (LV-siRNAs). Control rats were infused in the same areas with LV expressing GFP. Fifteen days later, rats were trained to acquire i.v. cocaine or heroin self-administration (SA). At the end of behavioral experiments, in order to evaluate the effect of LV-siRNA on D1aR expression, rats were challenged with amphetamine and the brains were processed for immunohistochemical detection of cFos and D1aR. Control rats acquired i.v. cocaine and heroin SA. Infusion of LV-siRNAs in the medial NAc shell reduced D1aR density and the number of c-Fos positive nuclei in the NAc shell, while sparing the core, and prevented the acquisition of cocaine, but not heroin SA. In turn, LV-siRNAs infusion in the core reduced D1aR density and the number of c-Fos positive nuclei in the same area, while sparing the shell, and failed to affect acquisition of cocaine. The differential effect of LV impairment of NAc shell D1aR on cocaine and heroin SA indicates that NAc shell DA acting on D1aR specifically mediates cocaine reinforcement.

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“…Addiction may be associated with abnormal activity in these pathways: although addicts continue to experience acute upsurges in DA levels in response to drug ingestion (Di Ciano et al 1995), there is increasing evidence from PET and SPET studies that by comparison with non drug users, abstinent addicts have fewer DA D2 receptors and show decreased DA release in the striatum (Dagher et al 2001;Volkow et al 1997Volkow et al , 2004.…”

Section: Introductionmentioning

confidence: 99%

A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning

et al. 2007

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Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine

Cited by 62 publications

References 0 publications

Distinct proteomic profiles of amphetamine self-administration transitional states

Distinct proteomic profiles of amphetamine self-administration transitional states

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning

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