Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain.

Abstract

CR oxycodone every 12 hours was as effective as IR oxycodone four times daily in managing moderate to severe cancer-related pain and was associated with fewer reports of adverse events.

Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review

“…One trial used both VAS and categorical scales. In one trial, where severity was investigator-rated, it is unclear which method was used (Kaplan et al, 1998).…”

“…The maximum number of patients enrolled in any one trial was 180. This was a multicentre trial involving 17 centres (Kaplan et al, 1998). In general, the multicentre trials recruited larger numbers of patients than the single-centre trials.…”

“…Patients recently or currently receiving radiotherapy and/or chemotherapy were specifically excluded in 20 of 34 trials. In two of these trials (Kaplan et al, 1998;Parris et al, 1998), the protocol was subsequently changed to facilitate patient inclusion.…”

“…In two of these (Deschamps et al, 1992;Stambaugh et al, 2001), the description was restricted to the location of the pain. Five trials (Hays et al, 1994;Bruera et al, 1996Bruera et al, , 1998Bruera et al, , 2004Hagen and Babul, 1997) evaluated patients using the Edmonton staging system which classifies pain as visceral, Kaplan et al (1998) 180 (M) Parallel group 6 days 16 (9%) VRSpi 4 11 0/spontaneous report of nervousness, anxiety 20 Klepstad et al (2003) 40 (S) Parallel group p7 days 6 (15%) VASpi; VRSpi 5 11 'Loss of sleep'; HRQOL/HRQOL: ND; sleep data NR 21 Knudsen et al (1985) 18 (S) Crossover 14 days 2 (11%) VASpi 4 10 22 Lauretti et al (2003) 26 (S) Crossover X35 days 4 (11%) VASpi 4 10 23 Melzack et al (1979) 44 (S) Crossover 'About' 4 weeks 14 (32%) PPI 4 9 24 Mignault et al (1995) 19 (S) Crossover 10 days 8 (42%) VASpi; VASpr 4 7 25 Moriarty et al (1999) 100 ( Parris et al (1998) 111 (M) Parallel group 5 days 37 (33%) VRSpi 4 16 29 Portenoy et al (1989) 51 (S) Parallel group Max. 5 days 2 (4%) VRSpi 4 11 'Quality of sleep'/ND 30 Stambaugh et al (2001) 30 (S) Crossover Max.…”

Early oral analgesia after fast-track cardiac anesthesia

“…We observed that the commonly reported opioid side effects 6,[31][32][33][34] were present with both regimens, namely, somnolence, dizziness, pruritus, nausea and vomiting. Respiratory depression, one of the most concerning side effects of opioid medications, was not observed in either group, nor were there any acetaminophen-related side effects, including hepatotoxicity.…”