Comparison of Cyclosporine Versus Mycophenolate Mofetil on Expression of Fractalkine and CX3CR1 in Chronic Allograft Nephropathy

Cao, Guorui; Lu, Yiping; Gao, Rui; Yu, Xin; Teng, D.; Wang, J.; Wang, L.; Li, Y.

doi:10.1016/j.transproceed.2006.06.046

Cited by 2 publications

(2 citation statements)

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“…10,[13][14][15][16][17][18][19][20][21][22][23] The following combinations such as Fisher 344-to-LEW, DA-to-BN, DA-to-WF, DA-to-LEW, SD-to-WF, and LEW to-BN have been used to induce CAN, with both advantages and disadvantages to each model. [23][24][25][26][27][28][29][30][31][32][33] However, since the Fisher 344-to-LEW model of RT is the most commonly employed in experimental studies, the establishment and application of this combination is described in detail.…”

Section: Strains Of Ratsmentioning

confidence: 99%

“…74 Fractalkine is a unique chemokine that functions both as a potent chemoattractant molecule (soluble form)1 and as an adhesion molecule (membrane anchored form) for cells expressing the fractalkine receptor CX3CR1, such as monocytes, NK (natural killer) cells, and subsets of CD8 + T-cells, involved in chronic transplant arteriosclerosis. Cao et al 32 demonstrated increased expression of the fractalkine receptor CX3CR1 in the SD-to-WF model of RT. Fractalkine/ CX3CR1 was mostly expressed in the tubulointerstitium and tubular epithelial cell basolateral membrane.…”

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confidence: 99%

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Experimental rat models of chronic allograft nephropathy: a review

Shrestha¹,

Haylor²

2014

IJNRD

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Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT can be technically challenging, it is attractive because the pathogenesis of CAN is similar to that following human RT and the pathological features of CAN develop within months as compared with years in human RT. The rat model of RT is considered as a useful investigational tool in the field of experimental transplantation research. We have reviewed the literature on studies of rat RT reporting the donor and recipient strain combinations that have investigated resultant survival and histological outcomes. Several different combinations of inbred and outbred rat combinations have been reported to investigate the multiple aspects of transplantation, including acute rejection, cellular and humoral rejection mechanisms and their treatments, CAN, and potential targets for its prevention.

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