Comparison of different adjuvant therapy regimen efficacies in patients with high risk of recurrence after radical resection of hepatocellular carcinoma

Xu, Feng; Feng, Guoying; Tao, Jie; Ao, Yupei; Wu, Xinhua; Qi, Shiguai; Shi, Zhonghua

doi:10.1007/s00432-023-04874-0

Cited by 4 publications

(1 citation statement)

References 74 publications

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“…Numerous prospective and retrospective studies on postoperative adjuvant therapy of HCC with MVI have achieved positive results. 33 , 34 The results of the IMbrave 050 study released in 2023 showed atezolizumab plus bevacizumab could potentially fulfill the anti-relapse effect on HCC patients with a high risk of recurrence. MVI was one of the inclusion criteria and accounted for 60.8% of patients in the experimental group.…”

Section: Discussionmentioning

confidence: 99%

A Grading System of Microvascular Invasion for Patients with Hepatocellular Carcinoma Undergoing Liver Resection with Curative Intent: A Multicenter Study

Wang,

Chen,

Yin

et al. 2024

JHC

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Background Microvascular invasion (MVI) is closely correlated with poor clinical outcomes in patients with hepatocellular carcinoma (HCC). A grading system of MVI is needed to assist in the management of HCC patient. Methods Multicenter data of HCC patients who underwent liver resection with curative intent was analyzed. This grading system was established by detected number and distance from tumor boundary of MVI. Survival outcomes were compared among patients in each group. This system was verified by time-receiver operating characteristic curve, time-area under the curve, calibration curve, and decision curve analyses. Cox regression analysis was performed to study the associated factors of prognosis. Logistic analysis was used to study the predictive factors of MVI. Results All patients were classified into 4 groups: M0: no MVI; M1: 1~5 proximal MVIs (≤1 cm from tumor boundary); M2a: >5 proximal MVIs (≤1 cm from tumor boundary); M2b: ≥1 distal MVIs (>1 cm from tumor boundary). The recurrence-free survival (RFS), overall survival (OS), and early RFS rates among all the individual groups were significantly different. Based on the number of proximal MVI (0~5 vs >5), patients in the M2b group were further divided into two subgroups which also showed different prognosis. Multiple methods showed this grading system to be significantly better than the MVI two-tiered system in prognostic evaluation. Four multivariate models for RFS, OS, early RFS, late RFS, and a predictive model of MVI were then established and were shown to satisfactorily evaluate prognosis and have a great discriminatory power, respectively. Conclusion This MVI grading system could precisely evaluate prognosis of HCC patients after liver resection with curative intent and it could be employed in routine pathological reports. The severity of MVI from both adjacent and distant from tumor boundary should be stated. A hypothesis about two occurrence modes of distal MVI was proposed.

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Section: Discussionmentioning

confidence: 99%