Comparison of different high resolution multifocal electroretinogram recordings in patients with age-related maculopathy

Chan

Survey of Ophthalmology

et al. 2007

Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

Section: Clinical Applications Of Mferg In Acquired Retinal Diseases mentioning

confidence: 97%

Section: Basics Of the Multifocal Electroretinographymentioning

confidence: 99%

Section: Basics Of the Multifocal Electroretinographymentioning

confidence: 99%

Section: Clinical Applications Of Mferg In Acquired Retinal Diseases mentioning

confidence: 99%

See 2 more Smart Citations

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Chan

Survey of Ophthalmology

et al. 2007

“…Various studies have reported the efficacy of the mfERG in the assessment of ARMD [6,19,20,29,33,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Multifocal Ergmentioning

confidence: 99%

The electroretinogram: a useful tool for evaluating age-related macular disease?

et al. 2010

With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease.

Assessment of Multifocal Electroretinogram Abnormalities and Their Relation to Morphologic Characteristics in Patients With Large Drusen

Gerth

Hauser²,

Delahunt³

et al. 2003

Arch Ophthalmol

To determine the extent of functional changes in the first-order kernel multifocal electroretinogram (mfERG) responses in patients with large drusen by means of a localized analysis and to determine correlations between mfERG responses and morphologic changes. Methods: Thirty-one eyes from 20 patients ages 58 to 84 years with large drusen (Ն5 drusen Ն63 µm diameter) were studied. The mfERGs were recorded with a stimulus of 103 hexagons and a flash intensity of 2.67 candela (cd)•s −1 •m −2. Each of the 103 single first-order kernel mfERG responses was analyzed and compared with those of age-matched healthy control subjects. Imaging studies, including color stereo fundus photography, red-free fundus photography, and fluorescein angiography, were performed in all patients, and morphologic changes (drusen in red-free fundus photography, staining or window defect in fluorescein angiography) were determined with a digital measurement tool. The mfERG responses were correlated to areas with and without morphologic changes. Results: Reduced responses were found in 10.0% (scalar products) and 4.0% (response densities) and delayed implicit times in 13.8% (N1), 18.9% (P1), and 23.8% (N2) of all mfERGs. Abnormal mfERG responses extended up to 25°in radius. Significant morphologicfunctional relations were detected in only a few patients. Abnormal mfERG variables were present in areas without morphologic changes. Conclusions: Patients with large drusen exhibit functional changes in the cone-driven pathways evaluated by the mfERG, indexed particularly by implicit times. Morphologically visible changes do not predict retinal function. Large drusen are associated with a more general retinal dysfunction.