Objective. To discuss and compare the effects of three different surgical procedures on ankle function rehabilitation of patients with Hepple V talus osteochondral injury. Methods. A total of 60 patients with Hepple V talus osteochondral injury admitted to our hospital from January 2020 to January 2021, among which 17 patients in study group 1 received microfracture surgery, 20 patients in study group 2 received osteochondral autologous transplantation, and 23 patients in study group 3 received with periosteal iliac bone transplantation. The range of motion (ROM) of the patients’ angle was evaluated by the goniometer before and after the treatment. The ankle function was evaluated by the ankle-hindfoot score of American Orthopedic Foot and Ankle Society (AOFAS). The ankle joint pain was evaluated by visual analogue score (VAS). The surgical efficacy was evaluated 12 months after surgery, and complications and nursing satisfaction were observed and recorded. Results. There was no significant difference in ROM, AOFAS score, and VAS score among the three groups before the treatment (
P
>
0.05
). ROM and AOFAS score of the three groups were improved, and VAS score was decreased at 6 months and 12 months after treatment (
P
<
0.05
). ROM and AOFAS score of group 2 and group 3 were higher than those of group 1, while the VAS score was lower than that of group 1, indicating significant difference (
P
<
0.05
). There was no significant difference in ROM, AOFAS, and VAS score between group 2 and group 3 (
P
>
0.05
). The surgical efficacy of group 2 and group 3 was higher than that of group 1, indicating statistical significance (
P
<
0.05
), while there was no significant difference in the surgical significance between group 2 and group 3 (
P
>
0.05
). There was no significant difference in complication rate among the three groups (
P
>
0.05
), and the treatment satisfaction of group 2 and group 3 was higher than that of group 1, indicating statistical significance (
P
<
0.05
), but there was no significant difference between group 2 and group 3 (
P
>
0.05
). Conclusion. Three different surgical procedures have good therapeutic effect for Hepple V talus osteochondral injury. Osteochondral autologous transplantation and periosteal iliac bone transplantation can reduce the pain of ankle joint, promote the effect of ankle joint function recovery, which can effectively improve patient satisfaction. It is suggested to choose the surgical procedure according to the actual situation of patients.