Comparison of Different Methods Used in the Preparation of Leucocyte‐Free Whole Blood and Erythrocyte Concentrates

Abstract

Abstract. The authors studied the degree of qualitative and quantitative deleucocytation of whole blood that can be obtained by washing and filtering. Based on the studies of 20 samples of blood it was established that successful deleucocytation can be expected only it combined procedures of washing and filtering are employed. The purpose of our present investigations was to determine to what extent can whole blood be deleucocyted by using current methods of blood preservation, or by combining these methods, as well as to assess the degree of damaging effects on red blood cells produced by these methods.

Leukoreduced red cell concentrates: Are they meeting the quality standards?

“…Still, leukoreduction obtained in our study was consistent with the values from previous studies on manual washing by other investigators. [ 11 12 ]…”

IgM Lymphocytotoxic Antibodies Following Multiple Transfusion

“…STOCKER et al [20], discussing their finding of IgM lymphocytotoxic antibodies in 3 patients who had rejected renal allografts while on immunosuppression, suggested that synthesis of IgM antibodies might not be suppressed by current regimes. Careful separation of virtually all white cells [15] and additional measures such as the organisation of autologous transfusion programmes [l] may be necessary to prevent the production of leucocyte antibodies.…”