Comparison of different root canal sealers: cytotoxicity and the type of induced cell death

Evaluation of cytotoxic and genotoxic effects of two resin-based root-canal sealers and their components on human leucocytes in vitro

“…(2008) reported that both Epiphany and RealSeal remained severely cytotoxic over the period of 6 weeks on L929 cells. However, in vitro cytotoxicity study on human laryngeal carcinoma HEp2 cells as the model system showed that Epiphany induced necrosis as the predominant type of cell death (Brzovic et al. 2009a).…”