Comparison of Different Tests for Deviation from Hardy-Weinberg Equilibrium of AMPFLP Population Data

Hou, Yiping; Prinz, Mechthild; Staak, M

doi:10.1007/978-3-642-78782-9_141

Cited by 70 publications

(26 citation statements)

References 3 publications

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“…No evidence of deviation from Hardy-Weinberg equilibrium in these populations was observed by the modified χ 2 -test (Hou et al 1994b). Pairwise comparisons between populations show that the distribution of allele frequencies is significantly different among the main ethnic groups.…”

Section: Population Geneticsmentioning

confidence: 68%

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D20S161 data for three ethnic populations and forensic validation

Hou¹,

Jin²,

Li³

et al. 1999

International Journal of Legal Medicine

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In order to evaluate the forensic applicability of the STR locus D20S161 and construct a preliminary database, the genotype distributions and allele frequencies in five populations from three main ethnic groups were investigated, including Germans, Slovakians, African Americans, Japanese and Chinese. A total of 512 samples from unrelated individuals and 85 confirmed father/mother/ child triplets were analyzed by PCR and allele determination was carried out by comparison with a sequenced human allelic ladder. The results showed that D20S161 typing was both precise and reliable. A total of 7 alleles was found in these populations and no evidence of deviation from Hardy-Weinberg equilibrium was observed. Pairwise comparisons between populations showed that there were significant differences in the distributions of the allele frequencies among the three main ethnic groups. No mutation events were observed from the confirmed father/mother/child triplets. With a maximum likelihood method, the mutation rate was indirectly estimated as 2.5 x 10(-5). These results suggest that D20S161 is a useful marker for forensic casework and paternity analysis.

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Section: Population Geneticsmentioning

confidence: 68%

“…A modified χ 2 -test (Hou et al 1994b) was used to verify whether the genotype distribution conformed to Hardy-Weinberg equilibrium predictions. The expected heterozygosity was calculated according to the equation h = 2n(1-ΣXi 2 )/(2n-1) (Nei 1978).…”

Section: Statistical Calculationsmentioning

confidence: 99%

D20S161 data for three ethnic populations and forensic validation

Hou¹,

Jin²,

Li³

et al. 1999

International Journal of Legal Medicine

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“…formed to Hardy-Weinberg equilibrium predictions [14]. A PowerStats program was used to calculate heterozygosity (http://www.promega.com).…”

Section: Polymorphism Of Strsmentioning

confidence: 99%

A novel diagnostic strategy for trisomy 21 using short tandem repeats

Yan

Jin

et al. 2006

Electrophoresis

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Molecular technique with STRs can rapidly diagnose aneuploidy. In order to improve its fidelity, we developed a novel STR-based strategy for fast diagnosis of trisomy 21 and constructed a multimarker diagnostic system according to it. The system is based on nine STRs, of which two were previously known and seven were newly identified from the genomic sequence of the long arm of chromosome 21. They were confirmed to be highly polymorphic in the Chinese population by PCR amplification and gel electrophoresis. The combination of nine STR markers, when applied to DNA from 102 Chinese individuals with normal karyotype, did not yield any false-positives, and clearly revealed three different alleles in DNA from 15 out of 18 trisomy 21 patients. The results show that our new strategy can provide an alternative molecular technique for the rapid detection of aneuploidy.

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“…An allele frequency distribution comparative analysis was done using the SAS system between our data and the data from eastern Chinese [4], western Chinese [5], Luoba ethnic population in Tibet [6], Macau Chinese [7], Korean population [8] and Malays in Malaysia [9] according to Hou's method [10]. No significant differences were found between eastern Chinese (n = 100) and our samples, or between western Chinese (n = 260) and our samples, or between Macau Chinese (n = 87) and our samples.…”

mentioning

confidence: 99%