Comparison of Effect of Antidepressants on Psychomotor Functions

Abstract

Objective:The comparison of the effect of antidepressants on psychomotor functions in patients with endogenous depression.Materials and Methods:This prospective interventional study was carried out at a tertiary care teaching hospital on 95 literate patients with newly diagnosed endogenous depression matching inclusion and exclusion criteria. Patients were prescribed either desvenlafaxine (50 mg) or fluoxetine (40 mg) or sertraline (50 mg). Psychomotor functions were assessed by digit letter substitution, six letter cancellation, choice reaction time, hand steadiness and flicker fusion test at the baseline 1st month and 3rd month. Efficacy of drugs was also measured by Hamilton rating scale for depression. Data were analyzed by using ANOVA and P < 0.05 was considered as statistically significant.Results:A total of 95 patients were enrolled. Fluoxetine, desvenlafaxine, and sertraline were prescribed in 32, 32, and 31 patients, respectively. At the end of 3 months, a significant improvement in psychomotor functions was observed in patients treated with sertraline (P < 0.05), while desvenlafaxine-treated patients did not show any significant change in any of the tests. Surprisingly, fluoxetine-treated patients showed deterioration in all psychomotor tests (P < 0.05). Hamilton rating score improved at the end of 3 months treatment as compared to baseline. Most commonly observed adverse reactions in all three drug groups were nausea (n = 20), dizziness (n = 3), headache (n = 20), and diarrhea (n = 3).Conclusion:Sertraline significantly improves psychomotor function as compared to desvenlafaxine while fluoxetine impairs.

Comparison of the Effects of Antidepressants on Cognition Functions in Patients of Major Depressive Disorders in Tertiary Care Hospital in Haryana

“…On intergroup analysis, the mean HAM-D score was compared between Group F and Group V; it was observed that the difference in mean HAM-D score at 3 rd , 6 th , 9 th , and 12 th weeks interval was clinically as well as statistically nonsignificant. A similar study was conducted by Mendhe et al [12], study revealed that on comparing the efficacy of the antidepressants, all the groups showed a significant reduction in mean scores at the end of the 1 st month and 3 rd month as compared to the baseline values. However, no statistically significant difference was observed at the end of 3 months of treatment among the different groups.…”

“…However, the importance of the present study cannot be undermined. Studies are available which show the effect of antidepressants on cognitive functions but most of these studies are single-dose studies, and studies of the same class of antidepressants [21].…”

Non-REM sleep in major depressive disorder

“…Patients from Dataset B performed the task both in unmedicated and medicated state, providing a source of practice. Additionally, long-term medication might have induced partial psychomotor performance deficits [72, 73] affecting the procedural baseline levels, and thus also limit its subsequent consolidation. This was not observed in the group with short-term medication, which also showed higher baseline levels and may have benefited from previous training before medication onset.…”

Effect of repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD) on cognitive control

“…Because certain drugs can have positive or negative effects on cognitive control and/or psychomotor function (Culang et al, 2009;Mendhe et al, 2017) and interact with rTMS (Breden Crouse, 2014;Hunter et al, 2019), medication effects may have contributed to some of the findings presented here.…”