Comparison of German population data on the apoB-HVR locus with other Caucasian, Asian and Black populations

Pöltl, Roger; Luckenbach, C.; Reinhold, J.; Fimmers, Rolf; Ritter, H.

doi:10.1016/0379-0738(96)01917-2

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…As established previously, 2,3,5,7,8,12 this locus is extremely polymorphic in individuals and significant diversity has been found for allele spectra in groups of different origin; similar results were observed here. We have tested populations of Mongoloid and Caucasoid origin, belonging to different linguistic families (Indo-European, Altaic and North Caucasian).…”

Section: Discussionsupporting

confidence: 79%

“…Higher rates of polymorphism have been found for populations of different origin and ethnicity. 2,5,7,8,12 In this study, we analysed the allele frequencies of the 3 0 ApoB HVR locus in normal individuals from 10 different populations (five Russian, two Byelorussian, and the Adygei, Kalmyk and Yakut) living in the Russian Federation and the Republic of Belarus.…”

Section: Introductionmentioning

confidence: 99%

“…2 -20 This HVR polymorphism has been widely used in investigations of the history and diversity of humans, both worldwide and in individual population groups. 2,5,7,8,12,19 It is considered a suitable locus for a pilot study of the relationships between the shape of allele-size distributions of minisatellites and the micro-evolutionary processes leading to their presentday distribution. 2 The allele-size frequencies can be used to calculate interpopulation genetic distances.…”

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein B 3′-VNTR polymorphism in Eastern European populations

et al. 2003

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Apolipoprotein B 3 0 (3 0 ApoB) minisatellite polymorphism was studied in healthy unrelated individuals from the Russian Federation and the Republic of Belarus, in 10 populations from five ethnic groups: Russians, Byelorussians, Adygeis, Kalmyks and Yakuts. The analysis was carried out using PCR and electrophoresis followed by silver staining. Overall, 25 alleles of the 3 0 ApoB minisatellite, ranging from 25 to 55 repeats, were detected. Heterozygosity indices were high and varied from 0.73 to 0.84. The distributions of alleles of this minisatellite in the Caucasoid populations (Russians, Byelorussians and Adygeis) had a bimodal character, whereas that for Mongoloid populations (Kalmyks and Yakuts) had a unimodal distribution. Nei's genetic distances between the populations studied and some reference populations of Europe and Asia were estimated. Despite their allele distribution homogeneity, different East Slavonic ethnic groups were clearly resolved by multidimensional analyses. The East Slavonic and Adygei populations revealed a high similarity with European Caucasoids. The Mongoloid populations (Kalmyks and Yakuts) were considerably different from those of the European Caucasoid populations, but were similar to other Asian Mongoloid populations. The results demonstrate the variability of 3 0 ApoB minisatellite polymorphism not only in distant populations but also, to a certain extent, in genetically relative ones.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein B 3′-VNTR polymorphism in Eastern European populations

et al. 2003

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“…The allele-size frequencies can be used to calculate interpopulation genetic distances. Higher differences in the level of polymorphism have been found in populations with different origins and ethnicities (Buresi et al, 1996;Destro-Bisol et al, 2000;Renges et al, 2002;Kravchenko et al, 1996;Poltl et al, 1996).…”

Section: The 3apob Minisatellite Polymorphism In Human Population Rementioning

confidence: 99%

“…The 3APOB polymorphism has been used widely in investigations of the history and diversity of humans, both worldwide and in individual population groups (Buresi et al, 1996;Destro-Bisol et al, 2000;Renges et al, 2002;Kravchenko et al, 1996;Poltl et al, 1996;Zago et al, 1996;Verbenko et al, 2005). It has been considered as a suitable locus for a pilot study of the relationships between the shape of allele-size distributions of minisatellites and the microevolutionary processes leading to their present-day distribution (Destro-Bisol et al, 2000).…”

Section: The 3apob Minisatellite Polymorphism In Human Population Rementioning

confidence: 99%

Minisatellite DNA Markers in Population Studies

Limborska¹,

Khrunin²,

Verbenko³

2012

Studies in Population Genetics

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Allele Frequency of VNTR Locus D1S80 Observed in Denizli Province of Turkey

Köseler

Atalay

2009

Biochem Genet

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The variable numbers of tandem repeats (VNTR) locus D1S80, located on chromosome 1 (1p35-36), has a repeat unit 16 bp in length, and different numbers of these repeat units have been observed for populations of different origins and ethnicity. We used a molecular identification method based on capillary electrophoresis separation to analyze D1S80 locus polymorphism among 74 subjects from Denizli province, Turkey, finding an amplified fragment length size of 379-635 bp. Allele repeat numbers were deduced from these sizes and sequence comparison. The most common alleles were repeat units 24 (34.3%) and 18 (22.4%), with frequencies of 0.414 and 0.207, respectively. Other alleles were 25 (7.86%), 28 (5.71%), 22 (4.25%), and 29 (2.86%). The allele with 23 repeat units was not observed. Results were in Hardy-Weinberg linkage disequilibrium. Observed heterozygosity was 0.614, and expected heterozygosity was 0.787. Theta(k) value was 4.86 (95% confidence interval limits). Capillary electrophoresis is a powerful approach for accurate identification of VNTR loci, especially for low base pair units like D1S80, for prenatal diagnosis, linkage analysis, forensic identification, paternity testing, anthropological research, and phylogenetic studies.

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Comparison of German population data on the apoB-HVR locus with other Caucasian, Asian and Black populations

Cited by 8 publications

References 10 publications

Apolipoprotein B 3′-VNTR polymorphism in Eastern European populations

Apolipoprotein B 3′-VNTR polymorphism in Eastern European populations

Minisatellite DNA Markers in Population Studies

Allele Frequency of VNTR Locus D1S80 Observed in Denizli Province of Turkey

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