Comparison of hematological parameters in primary hypertensives and normotensives of Sangareddy

Abstract

Background: Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. Aim: The aim of present study was to evaluate the hematological changes in primary hypertension in Sangareddy, Andhra Pradesh. Materials and Methods:In the present study, a total of 100 patients diagnosed for primary hypertension and 100 normotensive subjects were included. All the participants after taking informed consent were subjected to detailed history and hematological analysis. Students-'t' test was used to find out the significance of differences. P values less than 0.05 was considered the level of significance. Result: It was observed that the mean values of Hemoglobin, Erythrocyte count, Hematocrit, MCH and MCHC were increased in primary hypertension while, the mean levels of MCV were found to be lower in the hypertensive group when compared to normotensive subjects. Conclusion: Hypertension has impact on hematocrit, hemoglobin, RBC count, WBC count and Platelet count which can be used for early detection of hypertensive prone individuals.

Association of hematocrit with blood pressure and hypertension

“…In our study, there was no significant difference in mean corpuscular hemoglobin concentration (MCHC) between HTN and NTN groups. These results are in contrast to those studies reported an increased or decreased level of MCHC in HTN subjects . The reason of this inconsistency may be related to the differences in population size and ethnicity.…”

“…Babu et al. in a case–control study containing 100 hypertensive patients and 100 normotensive subjects demonstrated that MCV appears to be inversely related to systolic and diastolic blood pressure . Consistent with these findings, we showed that compared to the control group MCV is decreased in HTN individuals.…”

“…Increase in HCT is usually accompanied by high blood viscosity and increase in RBC count. It has been shown that erythrocyte count is increased in hypertensive subjects which would increase blood pressure through imposing additional load on cardiovascular system . Consistent with these findings, HGB, major cytosolic protein in erythrocytes, was markedly increased in HTN group compared to the NTN population.…”

“…Consistent with these findings, we showed that compared to the control group MCV is decreased in HTN individuals. Decrease in MCV is an adaptive mechanism to decrease RBC‐induced hypertension and viscosity without compromising blood flow . In our study, there was no significant difference in mean corpuscular hemoglobin concentration (MCHC) between HTN and NTN groups.…”

“…The association between HGB and HTN was also investigated in a recent cross‐sectional study on Korean population in where they showed a positive association between HGB level with SBP and DBP . Some studies showed that mean corpuscular volume (MCV) is a hypertension‐related risk factor, whereas others showed no relationship between MCV and hypertension . Babu et al.…”