Comparison of High Sensitivity C-Reactive Protein Value for Steroid Sensitive Nephrotic Syndrome Patients With Steroid Resistant

Abstract

Nephrotic syndrome (NS) is the most common glomerulopathy in childhood. The incidence of NS in the United States and United Kingdom is 2-7 new cases per 100,000 children per year, with a prevalence ranging from 16 cases per 100,000 children, and is found to be higher in developing countries. Nephrotic syndrome is a chronic disease that requires longterm monitoring because one of the complications that can be caused is cardiovascular complications caused by hyperlipidemia. High Sensitivity C-Reactive Protein (hs-CRP) can be used as a cardiovascular predictor in NS patients.Objective : To determine the differences in the value of hs-CRP in steroid sensitive nephrotic syndrome patients with steroid resistance.Methods : Case control design in 36 pediatric patients with nephrotic syndrome who came to the outpatient and inpatient unit of H. Adam Malik Hospital Medan from August 2020 to December 2020. Sampling using consecutive sampling technique, conducted interviews with parents, physical and laboratory examinations to confirm the diagnosis of steroid sensitive and steroid resistant nephrotic syndrome. An unpaired t-test and Mann-Whitney test were analyzed to assess the comparison between variables.Result : All NS patients were 36 subjects, 25 subjects (69.4%) were male and 11 subjects (30.5%) were female. The mean age of the study subjects for steroid sensitive NS patients was 8.4 (SD 4.8) years, whereas for steroid-resistant NS patients was 10.4 (SD 4.7) years. There was no significant difference between the hs-CRP value of steroid sensitive nephrotic syndrome patients with steroid resistance. Conclusion :There is no significant difference between the hs-CRP value of steroid sensitive nephrotic syndrome patients with steroid resistance.