Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors

Abstract

Long-term results are reported in 23 patients and short-term results in 30 patients presenting with bone tumors treated by curettage or resection followed by implantation of hydroxyapatite (HA) or highly purified beta-tricalcium phosphate (␤-TCP), respectively. Mean follow-up was 97 and 26 months in cases involving HA implantation and ␤-TCP implantation, respectively. Radiographs revealed HA incorporation into host bone in all but two cases; moreover, no obvious evidence of HA biodegradation was observed. A single patient exhibited late deformity following implantation of HA. All grafted ␤-TCP was, at least partially, absorbed and replaced by newly formed bone. The mean period required for the disappearance of radiolucent zones between the ceramics and host bone was 17 weeks in HA and 9.7 weeks in ␤-TCP. Highly purified ␤-TCP appears to be advantageous relative to HA for surgical intervention in bone tumors consequent to the nature of remodeling and superior osteoconductivity.

Evaluation of O SSIFI ® as Alloplastic Bone Graft Material in Treatment of Periodontal Infrabony Defects

“…The biologic similarity to natural bone results in optimal biocompatibility and ensures that it is well tolerated by the body [5]. Moreover, it is claimed to be a unique bi-phasic hydroxyapatite and beta tricalcium phosphate having a bioceramic matrix that is inert and highly osteoconductive [6].…”

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

“…In vivo studies have proved that even after 9 months of implantation sintered HA remained at the site with hardly any sign of resorption [11,12]. To circumvent this problem, HA has been combined with more soluble phases such as β-tricalcium phosphate (β-TCP) [13][14][15][16]. Alternatively, more inherently soluble phases such as brushite/monetite have also demonstrated higher resorbability [17,18].…”

Biomaterial availability of magnesium substituted beta-tricalcium phosphate converted from sea urchin <i>Tripneustes gratilla</i> shell

“…34), 35) The FTIR and XRD spectra also indicated the product had been transferred into desired target within 24 h. Ceramic TCP material could exist in animal body for 48 months, which had the same period for bone remodeling cycle in human body. 14) Meanwhile, ¢-TCMP have been reported to exist in animal body for longer period when compared to commercial ¢-TCP. 16) Hence, ¢-TCMP is a proper bone implant for bone regeneration.…”