Comparison of In Vitro Dissolution Profiles of Oxcarbazepine-HP b-CD Tablet Formulations with Marketed Oxcarbazepine Tablets

Patel, Nirav; Chotai, Narendra P.; Patel, Jayvadan K.; Soni, Tejal; Desai, J U; Patel, R. P.

doi:10.14227/dt150408p28

Cited by 40 publications

(25 citation statements)

References 14 publications

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“…Korsmeyer-Peppas equation was applied and n values were obtained in the range of 0.44 to 0.78, which indicate non-fickian diffusion. It has been shown that in the case of hydrophilic polymers, swelling and erosion of the polymer occur simultaneously, and both of them contribute to the overall drug-release rate 46 .…”

Section: Kinetics Of Drug Releasementioning

confidence: 99%

Formulation and development of ophthalmicin situgel for the treatment ocular inflammation and infection using application of quality by design concept

Patel

Thakkar

Metalia

et al. 2016

Drug Development and Industrial Pharmacy

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Section: Kinetics Of Drug Releasementioning

confidence: 99%

Formulation and development of ophthalmicin situgel for the treatment ocular inflammation and infection using application of quality by design concept

Patel

Thakkar

Metalia

et al. 2016

Drug Development and Industrial Pharmacy

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“…The data for this study were derived from a Dissolution Technologies paper by Patel et al (12) concerning dissolution tests of various oxcarbazepine formulations. Since there was no table of raw data available in the paper, graphical tool g3data was applied to scan the original graph ( Figure 1 in the publication) and extract numbers.…”

Section: Case Study 3: Real-life Examplementioning

confidence: 99%

KinetDS: An Open Source Software for Dissolution Test Data Analysis

Mendyk¹,

Jachowicz²,

Fijorek³

et al. 2012

Dissolution Technol.

109

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Because drug quality is the focus for pharmaceutical industry and regulatory agencies, the in vitro dissolution test becomes a standard tool for characterization of manufactured products. However, results of the dissolution test must be expressed in mathematical terms; this is realized by fitting various models to the cumulative dissolution curves. The models might be either mechanistic or empirical. The fitting process requires software (e.g., KinetDS) for automation and determination of possible release mechanisms of drug substances from the dosage forms. The software is FOSS (Free Open Source Software) and is available at http://sourceforge.net/projects/kinetds/.

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“…The n values of all formulations are as reported in Table II and III. All formulations of solid dispersions were not fitting to a specific model (Patel et al, 2008).…”

Section: Kinetic Treatment Of Dissolution Datamentioning

confidence: 99%

Physicochemical characterization and solubility enhancement studies of allopurinol solid dispersions

Changdeo

Vinod

Shankar

et al. 2011

Braz. J. Pharm. Sci.

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Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with treatment of diuretic conditions. One of the major problems with the drug is that it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of allopurinol were prepared by solvent evaporation, kneading method, co-precipitation method, co-grinding method and closed melting methods to increase its water solubility. Hydrophilic carriers such as polyvinylpyrrolidone, polyethylene glycol 6000 were used in the ratio of 1:1, 1:2 and 1:4 (drug to carrier ratio). The aqueous solubility of allopurinol was favored by the presence of both polymers. These new formulations were characterized in the liquid state by phase solubility studies and in the solid state by differential scanning calorimetry, powder X-ray diffraction, UV and Fourier Transform Infrared spectroscopy. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure allopurinol, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Solid dispersion prepared with polyvinylpyrrolidone showed highest improvement in wettability and dissolution rate of allopurinol. Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics primarily as Non-Fickian diffusion. Therefore, the present study showed that polyvinylpyrrolidone and polyethylene glycol 6000 have a significant solubilizing effect on allopurinol.Uniterms: Allopurinol. Polyethylene glycol 6000. Solid dispersions. Closed melting method. Dissolution enhancement.Alopurinol é fármaco comumente utilizado no tratamento de gota crônica ou hiperuricemia associada com o tratamento em condições diuréticas. Um dos maiores problemas com o fármaco é que este é praticamente insolúvel em água, o que resulta em baixa biodisponibilidade na administração oral. No presente estudo, dispersões sólidas de alopurinol foram preparadas pela evaporação do solvente, pelos métodos de amassamento, de coprecipitação, de comoagem e fusão fechada para aumentar sua solubilidade em água. Transportadores hidrofílicos, como polivinilpirrolidona, polietilenoglicol 6000 foram utilizados nas proporções de 1:1. 1:2 e 1:4 (fármaco: transportador). A solubilidade aquosa do alopurinol foi favorecida pela presença de ambos os polímeros. Estas novas formulações forma caracterizadas no estado líquido pelos estudos de solubilidade de fase e no estado sólido pela calorimetria diferencial de varredura, difração de Raio-X, espectroscopia de UV e de IV com transformada de Fourier. As caracterizações do estado sólido indicaram que o alopurinol estava presente como material amorfo e embebido em matriz polimérica. Ao contrário da velocidade de dissolução lenta do alopurinol puro, a dispersão do fármaco nos polímeros aumentou consideravelmente a taxa de d...

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Comparison of In Vitro Dissolution Profiles of Oxcarbazepine-HP b-CD Tablet Formulations with Marketed Oxcarbazepine Tablets

Cited by 40 publications

References 14 publications

Formulation and development of ophthalmicin situgel for the treatment ocular inflammation and infection using application of quality by design concept

Formulation and development of ophthalmicin situgel for the treatment ocular inflammation and infection using application of quality by design concept

KinetDS: An Open Source Software for Dissolution Test Data Analysis

Physicochemical characterization and solubility enhancement studies of allopurinol solid dispersions

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