Comparison of ionic and non-ionic drug release from multi-membrane spherical aerogels

Synthesis and biomedical applications of aerogels: Possibilities and challenges

“…The loading of the drug in the aerogels can be carried out either during the sol-gel process itself, during the solvent exchange of the gels or by supercritical impregnation of aerogel depending on the drug stability and affinity for solvents (water, organic solvent, scCO 2 ) and for the aerogel matrix [17,18,30,172,200]. The release profile of the drug loaded into the aerogels will be dependent on the nature of the aerogel [171] and can be modified by using different methods like multi-membrane hydrogel formation, preparation of hybrid aerogels, surface derivatization of aerogels or aerogel post-coating [200][201][202][203].…”

“…The release profile of the drug loaded into the aerogels will be dependent on the nature of the aerogel [171] and can be modified by using different methods like multi-membrane hydrogel formation, preparation of hybrid aerogels, surface derivatization of aerogels or aerogel post-coating [200][201][202][203]. Finally, aerogels can also be endowed with magnetic properties for targeted release purposes like hyperthermia or focused drug delivery [204,205].…”

“…Hydrophobic silica aerogels are more stable against disintegration than hydrophilic silica aerogels and the drug payload is released in a more prolonged release pattern mainly governed by diffusion [201]. For bio-based aerogels, the aerogel source, the aerogel-drug interaction and the pH of the medium (simulated gastric or intestinal conditions) significantly influenced the release profile and mechanism of the loaded drug [30,171,184,200]. Aerogel source will influence the hydrophilicity of the carrier and will define the porous integrity of the material upon contact with the aqueous solutions [171].…”

Fast production of high-methoxyl pectin aerogels for enhancing the bioavailability of low-soluble drugs

“…They can also be used as carriers for prolonging release [7,30,31] and enhancing the bioavailabilities of low-soluble drugs [8,32].…”

Aerogels as drug delivery systems: In vitro and in vivo evaluations

“…Another work [8] describes the preparation of dry biodegradable alginate aerogels with multi-membranes using a multi-step sol-gel process with potential applications as carriers for drug delivery. The effect of the number of membranes was investigated regarding the loading and release of the model drugs nicotinic acid and theophylline.…”