Comparison of levels of antiretroviral drugs with efficacy in children with HIV infection

Abstract

Many HIV-infected children show ARV plasma levels out of the therapeutic range which demands a child-adjusted approach. However, larger studies are urgently needed in pediatric populations to define optimal reference values.

Role of the Pharmacist in Caring for Patients with HIV/AIDS: Clinical Practice Guidelines

“…56 Significant inter-and intra-patient variability of antiretroviral levels in children has been demonstrated, which supports the role of therapeutic drug monitoring in individualizing dosing calculations for pediatric patients. 57 There is a role for pharmacists in accurate calculation of pediatric doses of antiretrovirals (i.e., based on weight, body surface area, and/or age). Therefore, these patient characteristics should be confirmed at each visit to ensure appropriate adjustment of antiretroviral doses as children grow.…”

Pharmacokinetics of Lopinavir Determined with an ELISA Test in Youths with Perinatally Acquired HIV

“…The therapeutic drug monitoring (TDM) is a tool generally used to monitor plasma drug levels of antiretroviral drugs, being the plasma concentration of protease inhibitors (PIs) and non-nucleosidic reverse transcriptase inhibitors (NNRTIs) associated with the levels of viral suppression and drug toxicity. Unfortunately data about pharmacokinetics of these drugs in pediatric patients are limited [1,2].…”