Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy

Schuman, Joel S.; Wollstein, Gadi; Farra, Taline; Hertzmark, Ellen; Aydın, Ahmet; Fujimoto, James G.; Paunescu, Lelia Adelina

doi:10.1016/s0002-9394(02)02093-7

Cited by 146 publications

(110 citation statements)

References 33 publications

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“…The manual and automatic algorithms perform comparably. 14 To avoid introducing a subjective component into our analysis, we used the automatic algorithm. The automatic reference plane used for this study was 150 mm above the RPE, which had the best performance for glaucoma detection and correlation with visual function when compared with other reference planes positioned at 95 and 205 mm.…”

Section: Discussionmentioning

confidence: 99%

“…7,8,[12][13][14] The reproducibility of ONH measurements using the Stratus OCT (Carl Zeiss Meditec, Dublin, CA, USA) was reported recently to be sufficient, especially regarding the cup-to-disc ratios (CDRs). 15 Although OCT may give objective measurement with less variation than biomicroscopy, this in itself does not mean that it will be more accurate in estimating the actual disc measurements.…”

Section: Introductionmentioning

confidence: 99%

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Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement

Arnalich‐Montiel¹,

Muñoz-Negrete²,

Rebolleda³

et al. 2006

Eye

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Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement AbstractPurpose To determine agreement between slit-lamp indirect ophthalmoscopy and Stratus optical coherence tomography (OCT) when assessing cup-to-disc ratios (CDRs). Methods Twenty-five ocular hypertensive subjects and 56 patients with primary openangle glaucoma were included. Estimation of vertical (VCDR) and horizontal (HCDR) cupto-disc ratio with slit-lamp ophthalmoscopy was made by three glaucoma specialists along with OCT scanning of optic nerve head. Agreement between OCT and specialists was measured by intraclass correlation coefficients (ICC), Bland and Altman's scatterplots, and a regression coefficient of the average difference. Results The mean VCDR and HCDR was significantly higher (Po0.001) with OCT than that estimated by the specialists, with the difference ranging from 0.08 to 0.11, and from 0.13 to 0.18, respectively, depending on the specialist. Difference was higher (Po0.001) for cuppings below 0.3, and looses significance for larger VCDR cuppings (above 0.7). ICC for VCDR was 0.87 among specialists, and ranges from 0.82 to 0.75 when comparing OCT and specialists. ICC for HCDR was 0.83 among specialists and 0.74 between OCT and specialists. When data were plotted according to the Bland-Altman method, as the cupping increased, the agreement also increased. Conclusions There is very good agreement among the specialists when estimating CDRs by stereoscopic slit-lamp biomicroscopy. OCT shows higher values than the specialists; the greatest differences occurred when assessing small CDRs and the differences diminished as the cupping increased. These two methods of measurement are not interchangeable, and the difference must be considered, especially in discs with smaller CDRs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement

Arnalich‐Montiel¹,

Muñoz-Negrete²,

Rebolleda³

et al. 2006

Eye

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“…10,11 Schuman et al 10 used two OCT versions to demonstrate a high degree of correlation between automated and manual disc margin identification for disc area, C/D area ratio, cup area, cup volume and rim volume. Using TDOCT, Iliev et al 11 found only 10 of 49 disc shapes required no modification, with the majority of disc margin points positioned outside the evident edge of the RPE/ choriocapillaris complex, leading to an apparent enlargement of the disc.…”

Section: Discussionmentioning

confidence: 99%

“…9 Evidence from studies employing TDOCT has shown good agreement between manual and automated definitions of disc margin delineation, although these studies note that failure of proper disc margin recognition does occur. 10,11 Similarly, studies employing SDOCT have shown good agreement between automated and manual disc delineation methods; 12,13 however, statistically significant differences in ONH and RNFL parameters have been reported. 13 The purpose of this study was to investigate the impact of manual vs automated RPE/BM endpoint demarcation on the measurements of ONH and all sectoral RNFL thickness parameters in a group of normal, GS, and glaucoma patients participating in the Advanced Imaging for Glaucoma Study (AIGS) that demonstrate a wide range of glaucomatous damage.…”

Section: Introductionmentioning

confidence: 98%

The comparison of manual vs automated disc margin delineation using spectral-domain optical coherence tomography

Iverson

Sehi

2013

Eye

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Aims To examine the impact of manual vs automated disc margin delineation on optic nerve head (ONH) and retinal nerve fiber layer (RNFL) parameters using spectraldomain optical coherence tomography (SDOCT). Methods A prospective cohort study consisting of normal, glaucoma suspect (GS) and glaucoma patients who underwent ONH and RNFL measurements using SDOCT technology (RTVue; Optovue Inc.). The retinal pigment epithelium/Bruch's membrane (RPE/BM) complex end points were automatically determined first, and were manually redefined subsequently. Analysis of variance, coefficient of variation (COV), concordance correlation coefficient (CCC), and Bland-Altman plots were used for the analyses. Results Ninety-nine eyes of 50 subjects (age 68±10 years) consisting of 36 glaucoma, 56 GS, and 7 normal eyes were included. The RNFL thickness measurements were similar (P40.05) between the two methods of demarcation, except for the inferior-nasal sector (P ¼ 0.04). For the ONH measurements, the cup-to-disc (C/D) ratio and rim area showed significant differences between the two methods (Po0.001). COV/CCC values for the ONH parameters were as follows: cup area 17.6%/0.88; cup volume 7.4%/0.91; average C/D ratio 18.1%/0.78; rim area 25.3%/ 0.69; and rim volume 42.6%/0.71, respectively. CCC/COV values for the RNFL parameters were as follows: average 2.1%/0.98; inferiortemporal quadrant 8.1%/0.79; inferior-nasal quadrant INQ quadrant 12.6%/0.67; SNQ quadrant 7.8%/0.83; and STQ quadrant 7.8%/0.88, respectively. Conclusion An overall high agreement and moderate-substantial concordance was observed between the demarcation methods. Automated disc margin delineation of SDOCT can be used reliably in clinical practice.

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“…O exame foi considerado anormal quando pelo menos uma região testada apresentou-se com defeito severo, com significância estatística (p<0,01), ou dois defeitos moderados contíguos (p<0,02) em pelo menos dois exames confiáveis (23) .…”

Section: Campimetria De Frequência Duplicada -Fdtunclassified

Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma

Fasolo

Júnior

Barbosa

et al. 2013

Arq. Bras. Oftalmol.

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INTRODUÇÃOO diagnóstico de glaucoma, classicamente se tem baseado na observação do disco óptico com características glaucomatosas, associado a defeitos correspondentes de campo visual, geralmente com níveis estatisticamente alterados de pressão intraocular (1) . Contudo, nem sempre o diagnóstico é evidente, principalmente em suas fases precoces. Desta forma, outras modalidades propedêuticas têm sido investigadas com a finalidade de proporcionar uma detecção mais precoce do dano glaucomatoso (1)(2)(3)(4)(5) . O exame da camada de fibras nervosas da retina (CFN) com o uso da polarimetria de varredura a laser foi introduzido na propedêutica do glaucoma, com o objetivo de proporcionar o diagnóstico precoce da doença através da medida da espessura da CFN (6)(7)(8) . Vários autores salientam que os defeitos na CFN precedem, em até anos, os observados no campo visual (9,10) . A perimetria com estímulo azul em fundo amarelo é realizada nos mesmos princípios que a técnica convencional com fundo e estímulo brancos e baseia-se nos relatos que as células ganglionares Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma RESUMO

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Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy

Cited by 146 publications

References 33 publications

Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement

Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement

The comparison of manual vs automated disc margin delineation using spectral-domain optical coherence tomography

Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma

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